Miscarriage in First Trimester
Conditions
Brief summary
cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.
Detailed description
Pregnancies achieved by assisted reproductive technologies (ART) are closely monitored, therefore miscarriages that occur very early in the pregnancy are frequently meticulously recorded and reported. On the other hand, spontaneous abortion rates among naturally occurring conceptions are notoriously hard to quantify and are often overstated when using criteria from assisted reproductive technologies. Additionally, women who have undergone treatment with ART are a particular population with traits that can make them more vulnerable to spontaneous abortions. cfDNA would be extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test. This study aims to determine the level of cell-free DNA (cfDNA) in early pregnancy and compare the results with those of product of conception (POC) testing, in concordance with standard karyotyping.
Interventions
OTHERThis is a routine procedure, no intervention will be provided.
This is a routine procedure, no intervention will be provided.
Sponsors
Chinese University of Hong Kong
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Inclusion criteria
1. Age 18-45 years. 2. Women who attend the early pregnancy loss clinic or Patients who receive ART 3. Their partner, the biological father of the pregnancy
Exclusion criteria
* History of psychological/ psychiatric problem * Patient refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cell-free DNA (cfDNA) | 15 weeks | Determine the use of cfDNA to ascertain chromosomal causes of miscarriages |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of cell-free DNA | 15 weeks | To determine the level of cell-free DNA (cfDNA) in early pregnancy |
| Aneuploidy results from product of conception | 15 weeks | To compare the aneuploidy results from product of conception (POC), in concordance with standard karyotyping. |
Countries
Hong Kong
Contacts
Primary ContactPUI WAH JACQUELINE CHUNG
Backup ContactYee Lee Elaine NG
Outcome results
None listed