Shock, Septic
Conditions
Keywords
DIC score
Brief summary
Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC
Detailed description
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by excessive systemic activation of coagulation, resulting in both hemorrhage and thrombosis. DIC can progress rapidly into lifethreatening multiorgan failure. Under normal hemostatic conditions, clot formation and resolution are tightly regulated. In DIC, dysregulated activation of the coagulation system results in a consumptive coagulopathy and microvascular thrombosis. DIC is always a secondary process caused by a variety of underlying disorders (eg, sepsis, trauma, or malignancy), which can cause endothelial tissue damage and procoagulant exposure . This activates the coagulation cascade, which promotes fibrin production and deposition and consumption of clotting factors. The subsequent consumption of coagulation factors and platelets, inhibition of natural anticoagulants and fibrinolysis, and fibrin deposition result in the clinical picture of DIC: a bleeding diathesis accompanied by microvascular thrombosis that often leads to end-organ damage . The International Society of Thrombosis and Hemostasis and the Japanese Association for Acute Medicine scoring systems are useful for detection of the DIC in critically ill pediatric patients . The overall incidence of DIC to be 1.2%, using a scoring system comprised of etiologic factors, clinical features, platelet count, prothrombin time, fibrinogen, and fibrin degradation products (FDPs) . The DIC score, easily computed in real-time at the bedside with routine laboratory values, is associated with mortality for children with sepsis andshock. Diagnosis of DIC through test of the D-dimer. Accordingly, testing for Ddimer or FDPs may be helpful for evulating relationship between DIC score and mortality rate among children with shock .
Interventions
DIAGNOSTIC_TESTD_dimer
DIC score including FDPs,D\_dimer
Sponsors
Assiut University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Inclusion criteria
* All Children with shock and DIC will developed during the period from 1-1-2025 to 31-12-2025
Exclusion criteria
* Any shock not complicated with DIC
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC | Baseline | Data of the patients will be collected in the form of: * Personal history (age, sex), demographics including residence. * Clinical history and examination including diagnoses, vital signs and signs of shock, cause of shock if detected. * Therapeutic history including the use of continuous vasoactive medications, volume of blood products transfused and the presence of mechanical ventilation Laboratory investigation: The four laboratory components of the DIC score were determined from 1. Complete blood count (CBC). 2. Prothrombin time (PT) 3. Platelet count 4. FDP titer Scoring systems The score was determined within the first 12 h of admission, at this time the patient was on the highest cumulative dose of these medications and used as a marker for hemodynamic instability. DIC scores were computed when all four-laboratory component |
| Scoring system | Baseline | Component of the score 0 1 2 3 Max points possible Platelet count (/mm3 ) \>100,000 100,000\_51 ≤50,000 2 Fibrinogen (mg/dl) ≥100 \<100 1 FDP titer (mg/ml) ≤5 6\_40 \>40 3 prolonged PT (s)\<3 3\_6 \>6 2 Total score 8 All individual components are summed for a total of eight possible points. If d-dimer is used instead of FDP titer, then cutoff values for the DIC score are (0: ≤2 mg/l), (2: 2.1-8 mg/l) and (3: \>8 mg/l) Interpretation of total score: ≥5 points positive for DIC \<5 points: negative, but patients could still have on\_ overt DIC which could evolve into Frank DIC .If there is ongoing concern for DIC, Coagulation labs may be repeated in 12\_24 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sample size | Baseline | Eighty (80) children with shock will be included in this study during the period from 1-1-2025 to 31-12-2025. Sample size was calculated by Open Epi Info version (3) according to previous study conducted by Robinder., et al (2008), by comparing two related means using confidence level 85%. |
Contacts
Primary ContactNora AbdelHarithAmin
Backup ContactMahmoud AbdelFattah Ahmed
Outcome results
None listed