Healthy Control, Mental Disorders
Conditions
Keywords
schizophrenia, major depressive disorder, autism spectrum disorder, bipolar disorder, magnetic resonance imaging, multi-omics
Brief summary
This study focuses on the structure and function of the brain and gene expression in peripheral blood of patients with schizophrenia, to explore the interaction and influence between the three. Patients with mental disorders who have been recruited will take their medication regularly for 1 year and participate in baseline and follow-up assessments.
Detailed description
The study seeks to identify possible biological markers of schizophrenia and the effects of gene-environment interactions on brain structural and functional networks. So we can help doctors and scientific researchers better understand the neuropathological basis of schizophrenia.
Interventions
DRUGAntipsychotic drugs, antidepressants, mood stabilizers, and sleep aids
Patients with mental disorders should take the appropriate medicine as prescribed by the doctor，and the health norms are not required to take medicine.This study will not interfere with the medication regimen of doctors.
Sponsors
mingjun Zhong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
13 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 13-35 years old(Patients with healthy siblings can be extended to 14-35 years of age) * Course of disease: \<24 months * Priority is given to patients who have never taken medicine or duration of drug use \< 2 weeks * No nuclear magnetic contraindications.
Exclusion criteria
* Family history of psychotic disorders, history of psychoactive substances abuse, alcohol dependence, or nicotine dependence * Have a major physical disease or infectious disease * History of coma and serious neurological disease 4.MRI contraindications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cortical morphology | 40 minutes | Data were obtained using magnetic resonance scans |
| target gene charaacteristics | 1 day | 10ml peripheral blood was extracted for gene analysis |
| scale scores | 90 minutes. | The score of each dimension and the total score were calculated according to the scale.The scale includes three dimensions: negative symptom, positive symptom and general psychopathology, and the score range of each dimension is different. The total score ranges from 30 to 210, with higher scores indicating worse results. |
Countries
China
Contacts
CONTACTYunzhi Pan
Outcome results
None listed