Malnutrition
Conditions
Keywords
Malnutrition, Muscle mass, GLIM, chronic kidney disease
Brief summary
The goal of this observational study is to investigate how the GLIM criteria\* for the diagnosis of malnutrition should be operationalized in patients with chronic kidney disease (CKD) treated with hemodialysis. The main questions it aims to answer are: * How can malnutrition be defined when applying different combinations and operationalization strategies of the GLIM criteria? * How can information from other nutrition assessment tools be used in the operationalization of GLIM? * Which combinations and operationalization strategies of the GLIM criteria can best predict deterioration in quality of life, muscle strength, and increased mortality? This is an observational study on patients with CKD in hemodialysis. Variables are extracted from the Swedish renal registry, SNR and medical records at two hemodialysis units at one university hospital in Sweden. Data collection started in the fall of 2024, and are collected during two timepoints (baseline and follow-up) when wanted variables for this study are routinely measured at the units. Data on 2-year overall survival are also collected. * The Global Leadership Initiative on Malnutrition (GLIM) criteria to diagnose malnutrition in adults
Interventions
None listed
Sponsors
Umeå University
Uppsala University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥18 years * dialysis duration more than 3 months prior to recruitment
Exclusion criteria
* patients who only have a dialysis frequency of once a week * patients treated with a combination of peritoneal dialysis and hemodialysis or treated at home * patients were written consent cannot be obtained due to medical or mental illness or weakened state of health
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Malnutrition diagnosis | From Aug/Sept 2024 to May 2025 | Malnutition diagnosis according to GLIM |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle mass | From Aug/Sept 2024 to May 2025 | Muscle mass according to Bioimpedance Spectroscopy and Calf circumference |
| Overall survival | From Aug/Sept 2024 to Dec 28 | Overall survival |
| Muscle strength | From Aug/Sept 2024 to May 2025 | Hand grip muscle strength |
| Health related quality of life | Aug/Sept 2024 (baseline) | Health related quality of life according to RAND36 |
Countries
Sweden
Contacts
PRINCIPAL_INVESTIGATORSandra Einarsson, PhD
Umeå University
Outcome results
None listed