Osteoarthritis of Knee
Conditions
Brief summary
The goal of this clinical trial is to compare the effects of electrical dry needling versus glucosamine sulfate iontophoresis on pain intensity level, functional ability, and knee range of motion in chronic unilateral knee osteoarthritis patients.
Detailed description
Knee Osteoarthritis (OA) is a chronic disease affecting 240 million people worldwide, with a higher prevalence in older adults. The disease leads to knee deformity, laxity, and ligament instability. Dry needling, a new treatment modality, uses needle electrodes to deliver an electric current to the pain-generating trigger point, improving the physiological effects and analgesic and anesthetic effects. Iontophoresis, a safer method of drug therapy, has shown to be more effective in pain reduction in knee osteoarthritic patients. The study aims to investigate the effect of electrical dry needling versus glucosamine sulfate iontophoresis on pain intensity level, knee function, and range of motion (ROM) in chronic knee OA patients. This approach aims to maximize drug bioavailability, optimize therapeutic efficacy, and minimize side effects.
Interventions
OTHERconventional physical therapy
including transcutaneous electrical nerve stimulation (TENS) and an exercise therapy program (stretching exercises, both hip and knee strengthening, balance, and stability exercise)
In electrical dry needling, needle electrodes are used to deliver an electric current to the taut muscle band or the pain-generating trigger point. Low-frequency currents are thought to improve the physiological effects of the therapy by using electrical stimulation to enhance certain physiological reactions and achieve a speedier analgesic and anesthetic effect than that obtained with standard dry needling.
OTHERGlucosamine sulfate iontophoresis
Galvanic current mode will be used to deliver the cream through the skin. One gram of GS will be placed on positive electrode (being positively charged using Trans-arthral electrode placement technique) for administration of Iontophoresis \[40mA-min (2mA x 20minutes)\].
Sponsors
Horus University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
The sample will be randomly divided into three groups: A, B, and C. Group A: The control group (n=20) Group B: The study group (n=20) will receive conventional physical therapy plus electrical dry needling. Group C: The study group (n=20) will receive conventional physical therapy plus glucosamine sulfate iontophoresis.
Intervention model description
Randomized controlled trail, repeated measured; pre and post-test experimental design will be conducted
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. The patient will be selected from the outpatient clinic of physical therapy at Horus University, New Damietta, Egypt, diagnosed with a Kellgren/Lawrence grade 2,3 radiological severity of knee osteoarthritis (OA). and referred by an orthopedist. 2. Age will range from 40 to 60 years. 3. Body mass index will range from 25 to 29.9 kg/m2. 4. Duration of knee pain not less than 3 months prior to study .
Exclusion criteria
1. Patients with history of cardiac disorder with pacemaker. 2. Knee surgery. 3. Diabetes and nutritional disorder. 4. Neuromuscular and other musculoskeletal diseases. 5. Any red flags to dry needling, or conventional therapy. 6. Had received physical therapy, acupuncture, massage therapy, chiropractic, or intra-articular injections for the painful knee in the last 3 months. 7. Presented with positive neurological signs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity level measurement | at baseline and after 6 weeks | The visual analog scale (VAS) is a pain rating scale .A 10-cm line that represents a continuum between the two ends of the scale-no pain on the left end (0 cm) of the scale and the worst pain on the right end of the scale (10 cm) |
| Functional ability measurement | at baseline and after 6 weeks | Knee Injury and Osteoarthritis Outcome (KOOS) Score.A 0-100 scale, with zero express extreme knee problems and 100 for no knee problems, as common in orthopedic scales. |
| Knee ROM measurement | at baseline and after 6 weeks | A digital goniometer will be used to measure active knee ROM. The subject will be supine, flexing and extending their knee to the maximum. Bony landmarks will be identified for standardization and repeatability. The goniometer will be positioned over the lateral epicondyle of the femur, with the greater trochanter for reference. Measurements will be made three times, and the average value will be analyzed. Knee ROM measurements in patients with knee OA show high reliability. |
Countries
Egypt
Outcome results
None listed