Pelvic Deformity
Conditions
Brief summary
Pelvic floor disorders affect a large population of women and are responsible for a significant impairment in their quality of life, but the pathophysiology of these disorders is still poorly understood. The project proposes to define new ultra-fast 3D MRI sequences to capture the movements of the main pelvic organs. Visualization of 3D volumes is of great importance to clinicians, but data size hinders clinical use. This study is the first to propose a dynamic 3D representation of pelvic organs, together with quantitative estimates of the deformations undergone. The method is based on four steps: dynamic acquisition, organ segmentation, temporal reconstruction, quantification and visualization of deformations. The D3-Pelvis project responds to the challenge of technologies for health with dynamic 3D MRI acquisition and 3D modeling, offering prospects for diagnostic aids and simulators.
Interventions
DIAGNOSTIC_TESTdynamic MRI
* MRI sequences will be performed for patients and healthy volunteers i * Vaginal and rectal tagging will be performed using a water-based ultrasound gel. * The gel will be inserted by an authorized person (nurse or doctor) using a syringe with a conical tip and, optionally, a probe. * MRI sequences. * Data analysis and interpretation.
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult women, +/- of childbearing age, with or without effective contraception. * Informed consent signed prior to any procedure described in the study.
Exclusion criteria
* Contraindication to MRI, * Impossibility of performing the examination during thrust, * Minor patients * Pregnant or breast-feeding women, * Women of legal age under guardianship * Persons staying in a health or social institution, * People in emergency situations, * Persons not covered by a social security scheme, * Persons deprived of their liberty. * Specifically, women with IUDs will be excluded if they cannot remove them before the examination. * For healthy volunteers: history of colorectal surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Develop new three-dimensional analysis tools combining high spatial resolution static MRI with ultra-fast dynamic MRI. | 0 month | a metric for displacement of the anchor points of the targeted pelvic organs will be evaluated |
Countries
France
Outcome results
None listed