Lung Cancer
Conditions
Brief summary
The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes (never-smokers) in the United Kingdom. The main questions it aims to answer are: * To describe characteristics such as demographics, co-morbidities and environmental exposures * To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible * To describe participant outcomes such as cancer stage, treatment and mortality * To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data. Participants will currently have no change to their usual care.
Interventions
None listed
Sponsors
University College London Hospitals
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site
Exclusion criteria
* Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as: * More than 100 cigarettes or 75g tobacco in their lifetime * Those who have received a prescription for nicotine replacement therapy * For prospective participants, those who cannot consent will be excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demographics, comorbidities and environmental exposures of participants | Comorbidities and environmental exposures at diagnosis (approximately up to 156 weeks prior to diagnosis) | From review of electronic health records |
| Participant pathways including presentation mode and symptoms | Presentation mode and symptoms at time of diagnosis (approximately up to 52 weeks prior to diagnosis) | From review of electronic health records |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Participant outcomes such as cancer stage, treatment, mortality | Cancer stage at time of diagnosis, treatment and mortality through study completion (likely 5 years) | From review of electronic health records |
| Measurement of modifiable and non-modifiable factors associated with LCINS | Through study completion (likely 5 years) | To be determined |
Countries
United Kingdom
Contacts
Primary ContactNeal Navani, PhD
Backup ContactSindhu Naidu, MBBS
Outcome results
None listed