Apolipoproteins, Cardiovascular Diseases, Food Preferences, Functional Food, HDL, Low-density-lipoprotein-type, Triglycerides
Conditions
Keywords
PUFA, cardiovascular risk, lipid profile, healthy volunteers, yogurt, sacha inchi oil, interspecific hybrid palm oil
Brief summary
The purpose of this study was to assess the effect of the daily intake of yogurts enhanced with Sacha Inchi oil and hybrid palm tree oil on human plasma lipids related to cardiovascular risk factors
Detailed description
After being recruited and signing a written informed consent about the study and potential risks, the participants were randomized and assigned in a double-blind manner to one of three intervention groups (control yogurt, sacha inchi oil yogurt, or hybrid palm tree oil yogurt; consumption 1 bottle of 200ml per day for 90 days.
Interventions
OTHERSacha inchi oil yogurt
Sacha inchi oil was incorporated into a nonfat yogurt acting as a source of linolenic acid
OTHERHybrid palm oil yogurt
Interspecific hybrid palm oil was incorporated into a nonfat yogurt as a source of bioactive compounds
OTHERControl yogurt
Conventional full-fat yogurt
Sponsors
Universidad Nacional de Colombia
Pontificia Universidad Javeriana
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Forty-seven subjects were randomized and assigned to one of the three intervention groups supplemented daily with 200g of: Sacha Inchi Oil (SIO)-containing yogurt (Group-A), Hybrid palm oil (HPO)-containing yogurt (Group-B), and plain yogurt (Group-C).
Intervention model description
A pilot randomized; double-blind, parallel-controlled pragmatic trial was performed
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal total cholesterol (≤200mg/dl) levels * Have a yogurt consumption habit of at least three times a week * Maximum level of moderate physical activity * Body mass index (BMI) of ≤29.9kg/m2 * Serum triacylglycerols below 400mg/dl
Exclusion criteria
* Presence of chronic disease (Arterial hypertension, Diabetes Mellitus, among others) * A history of illicit drug use and/or chronic alcohol use, active smoking * A well-established allergy to red palm olein and/or milk and its derivatives * Consumption of nutritional supplements (antioxidants, omega 3, fiber, phytosterols) * Pregnancy or lactation * Having menopause * High consumption of nuts, flaxseed, chia, and sesame seeds
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma levels of total cholesterol | Baseline, 1 month, 2 months and 3 months | Measure in plasma (mmol/l) |
| Change in plasma levels of LDL-cholesterol | Baseline, 1 month, 2 months and 3 months | Measure in plasma (mmol/l) |
| Change in plasma levels of HDL-cholesterol | Baseline, 1 month, 2 months and 3 months | Measure in plasma (mmol/l) |
| Change in plasma levels of triacylglycerols | Baseline, 1 month, 2 months and 3 months | Measure in plasma (mmol/l) |
| Change in plasma levels of Apolipoprotein A1 (ApoA1) | Baseline, 1 month, 2 months and 3 months | Measure in plasma (g/l) |
| Change in plasma levels of Apolipoprotein B (ApoB) | Baseline, 1 month, 2 months and 3 months | Measure in plasma (g/l) |
| ApoB/ApoA1 ratio | Baseline, 1 month, 2 months and 3 months | prognostic predictor of a 10 year cardiovascular event |
Countries
Colombia
Outcome results
None listed