Negative Pressure Ventilation, Right Ventricular Dysfunction, Right Ventricular Failure
Conditions
Brief summary
Patients receives induction of general anesthesia for interventional tricuspidal clipping and standard monitoring for this procedure including arterial and central venous line and transesophageal ultrasound. A cuirass for extrathoracal negative pressure ventilation is placed onto the chest but not switched on. During usual positive pressure ventilation a ventilatory, a hemodynamic and a 3D full volume ultrasounddataset of the right and left ventricle is recorded and severity of tricuspidal regurgitation examined. Afterwards negative pressure ventilation is started and positive pressure ventilation reduced as far as possible without reduction of tidal volumes. The same dataset of ventilation, hemodynamics and ultrasound is collected again during negative pressure ventilation. Afterwards the cuirass gets removed, study finished and everything proceeds as during standard procedure.
Interventions
Substitution of positive pressure ventilation by negative pressure ventilation
Sponsors
Karlsburg Hospital
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients planned for tricuspidal clipping
Exclusion criteria
* ventilatory of hemodynamic instability * fitting of cuirass not possible * unavailability of examiner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| stroke volume index | 1 minute | transesophageal ultrasound measurement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| RVEF | 1 minute | transesophageal ultrasound measurement |
| LVEF | 1 minute | transesophageal ultrasound measurement |
| strain | 1 minute | transesophageal ultrasound measurement |
| VC | 1 minute | transesophageal ultrasound measurement |
| PISA | 1 minute | transesophageal ultrasound measurement |
| EROA | 1 minute | transesophageal ultrasound measurement |
| area of regurgitation of tricuspid valve | 1 minute | transesophageal ultrasound measurement |
| arterial blood pressures | 1 minute | hemodynamic measurements |
| venous blood pressures | 1 minute | hemodynamic measurements |
| volumes of chambers | 1 minute | transesophageal ultrasound measurement |
| heart frequency | 1 minute | hemodynamic measurements |
| tidal volume | 1 minute | ventilatory measurements |
| minute volume | 1 minute | ventilatory measurements |
| breathing rate | 1 minute | ventilatory measurements |
| etCO2 | 1 minute | ventilatory measurements |
| pO2 in the blood | 1 minute | blood gases |
| pCO2 in the blood | 1 minute | blood gases |
| Laktat | 1 minute | blood gases |
| cerebral oximetry | 1 minute | NIRS |
| pulmonal blood pressures | 1 minute | hemodynamic measurements |
Countries
Germany
Outcome results
None listed