Opioid Use Disorder
Conditions
Keywords
Opioid Use Disorder, Peer Recovery Coach, AI-driven text tool, mobile health (mHealth)
Brief summary
Black and Latinx people who use opioids are disproportionately impacted by opioid overdose deaths. The proposed study assesses the efficacy of an open source, multimodal artificial intelligence-driven texting tool combined with peer recovery coach-supported text contact that delivers social services, stigma reduction, health habitus, and patient navigation content addressing social determinants of health to enhance receipt of buprenorphine in primary care among emergency department-enrolled Black / Latinx people who use opioids.
Detailed description
The investigators have validated a theory-driven, artificial intelligence (AI)-driven texting tool using natural language processing to facilitate real-time text responses to patient queries combined with automated texts facilitating receipt of buprenorphine in office-based opioid treatment (OBOT) and social services that address social determinants of health (SDH). This open-source texting tool offers passive reminders, informational content, and interactive two-way response algorithms without personal staff contact. In addition, the investigators have adapted an efficacious cultural and structural humility training for PRCs that goes beyond SDH to also address stigma reduction, discrimination, health habitus, and patient navigation to enhance uptake of primary care and social services for PWUO. Using a three-arm, comparative effectiveness trial design, the specific aims are to: (1) Assess the efficacy of PRC supported text-based care/services coordination with PWUO + AI-driven SDH-enhanced text messaging (intervention arm-1) vs. AI-driven SDH-enhanced text messaging only (intervention arm-2) vs. Treatment as Usual (TAU) or printed social/medical services referrals (control) to enhance the receipt of buprenorphine in OBOT among community and ED-enrolled Black / Latinx PWUO (N=252); (2) Evaluate the implementation of the multimodal intervention (arm-1) guided by the RE-AIM and CFIR frameworks using in-depth interviews among 3 stakeholder groups: (a) frontline providers (n=10); (b) administrators (n=10); and (c) a subset of the Black and Latinx PWUO from the multimodal intervention arm-1 (n=30); and (3) Identify the resources and estimate the associated cost of implementing and sustaining the multimodal intervention and incorporate this information into a customizable budget-impact tool and conduct a comprehensive economic evaluation to calculate the relative economic value (e.g., cost-per quality-adjusted life years, cost-per OUD treatment days) of each study arm from the healthcare sector, state policymaker, and societal perspectives which will also inform implementation framed by RE-AIM.
Interventions
BEHAVIORALPRC supported text + AI driven SDH-enhanced text
This interventional study evaluates an AI-driven texting tool combined with peer recovery coach support to deliver social services, reduce stigma, and provide patient navigation content. The goal is to enhance the receipt of buprenorphine in primary care among emergency department-enrolled Black and Latinx individuals who use opioids, addressing the disproportionate impact of opioid overdose deaths on these communities.
BEHAVIORALAI driven SDH-enhanced text only
This interventional study evaluates an AI-driven SDH-enhanced texting tool to deliver social services, reduce stigma, and provide patient navigation content. The goal is to enhance the receipt of buprenorphine in primary care among emergency department-enrolled Black and Latinx individuals who use opioids, addressing the disproportionate impact of opioid overdose deaths on these communities.
BEHAVIORALTreatment as Usual (TAU)
Control Arm-3 will receive treatment as usual (i.e., verbal instructions, NYC Dept of Health pamphlets detailing access to OUD and social services, health system smartphone application EMR patient portal).
Sponsors
Friends Research Institute, Inc.
Nathan Kline Institute for Psychiatric Research
NYU Langone Health
Weill Medical College of Cornell University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
1. ≥18 years of age; 2. fluent in English and/or Spanish; 3. self-reported non-prescription opioid use \<30 days prior to consent; 4. provision of informed consent; 5. planned stay in NYC ≥12 month; 6. self-identified Black and/or Latinx race/ethnicity; 7. positive urine toxicology for opioids per EMR records; 8. diagnosis of OUD per the Diagnostic and Statistical Manual of Mental Disorders-5 9. self-reported interest in initiating buprenorphine in primary care 10. must have a mobile phone data plan.
Exclusion criteria
1. inability to comprehend text content written at a 3rd grade reading level; 2. physical or visual disability preventing mobile phone use; 3. self-reported receipt of medications for OUD in past 30 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of self-reported linkage to OUD services | 1 year | The primary outcome for this efficacy study is self-reported linkage to OUD services (i.e., time to initial buprenorphine prescription that is prescribed in OBOT programs or other OUD treatment providers per the Non-study Medical and Other Services form. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Office-Based Opioid Treatment with buprenorphine. | 1 year | Durability of treatment effect at 52 weeks. For example, continuous retention in Office-Based Opioid Treatment with buprenorphine. |
| Number of social services received | 1 year | Total number of social services received and documented over 52 weeks. |
| Number of interactions and time spent (in minutes) engaged with the intervention | 26 weeks | Total number of interactions and time spent (in minutes) engaged with the intervention over 26 weeks |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORBabak Tofighi, MSc, MD
Friends Research Institute, Inc.
Outcome results
None listed