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Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)

Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest in the North Finistère Population: Derivation and Validation of a Predictive Score

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06569134
Acronym
MIRA29
Enrollment
1200
Registered
2024-08-23
Start date
2022-07-24
Completion date
2025-01-24
Last updated
2024-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest, Cognitive Impairment, Neurologic Dysfunction

Brief summary

From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region. First step of the model derivation will consist in multivariate analysis to extract the most pertinent variates associated with neurological outcome (evaluated using the CPC Score); Second step will consist in the use of artificial intelligence and machine-learning to derive the most discriminant score.

Interventions

None listed

Sponsors

University Hospital, Brest
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Cardiac arrest requiring cardiopulmonary resuscitation

Exclusion criteria

* Death before cardiopulmonary resuscitation * Pediatric Patients

Design outcomes

Primary

MeasureTime frameDescription
Cognitive OutcomeFrom date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 monthsIt will be evaluated at the end of the ICU stay using the CPC score; a CPC score equal or below 2 will be considered as a good outcome, while a CPC \> 2 will be considered as a bad outcome

Secondary

MeasureTime frameDescription
Death OoHBefore hospital arrivalDeath after resuscitation during the prehospital care phase
Death ICUDuring ICU stayDeath within the ICU care
Death at Day 2828 days after cardiac arrestDeath at Day 28, before or after hospital discharge

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026