Celiac Disease in Children, Nutritional Deficiency, Quality of Life
Conditions
Brief summary
Celiac disease is a disorder commonly diagnosed during childhood. The treatment is a lifelong gluten-free diet. Both the condition and the diet can influence the children's physical and emotional well-being. The main goal of this observational study is to learn about nutritional status in a group of children with celiac disease compared to a group of healthy children. The nutritional assessment includes information on diet, biochemical measurement, and body composition. Quality of life will also be assessed. The study can contribute to ensure good health and well-being in children on a gluten-free diet.
Detailed description
* A 24-hour dietary recall will be done by a clinical dietician to assess intake of energy and micro- and macronutrients. * Blood will be drawn for assessment of vitamin- and mineral status. * Feces and urine samples will be collected to measure gluten immunogenic peptides (GIP) to assess exposure to gluten. * A self-developed interview will be used for assessment of adherence to the gluten-free diet and compared with the results from a 11-item questionnaire. * Weight and height will be measured. * Bone mineral density and body composition will be measured by dual-energy x-ray absorptiometry (DXA). * Health-related quality of life (QOL) will be measured by the PedsQL.
Interventions
None listed
Sponsors
University of Oslo
Oslo University Hospital
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* eating a regular diet
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Iron deficiency will be assessed from hemoglobin and ferritin in children with celiac disease and in healthy children. Differences in the prevalences of iron deficiency between children with celiac disease and healthy children will be described. | All participants will be assessed once. The study time frame is from August 2024 until December 2025. | Blood samples will be analyzed for blood hemoglobin and serum ferritin. |
Countries
Norway
Contacts
Primary ContactCathrine Aa Strandskogen, MSc
Backup ContactJanne A Kvammen, Phd
Outcome results
None listed