Coronary Artery Disease
Conditions
Brief summary
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy.
Detailed description
Recent landmark clinical trials on the use of colchicine in patients with chronic coronary artery disease has led to its implementation as an FDA approved drug for secondary prevention in patients with coronary artery disease. Colchicine exerts a range of anti inflammatory effects which plays a major role in reduction of atherosclerosis and prevention cardiovascular events. This current study aims to investigate the effect of colchicine on platelet reactivity in patients with stable coronary artery disease already on dual anticoagulants.
Interventions
Blood samples will be collected from participants in 2 separate instances. Initially, a baseline VerifyNow P2Y12 PRU and Aspirin reaction unit test assay, followed by a subsequent repeat test 2-week after a 2-week, colchicine 0.5mg oral tablet twice-daily
Sponsors
The University of The West Indies
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients with stable coronary artery disease. * Patients older than 18 years of age. * Patients currently on dual anti platelets, aspirin and clopidogrel
Exclusion criteria
• Patients already on colchicine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| P2Y12 reaction units and Aspirin reaction units | two weeks | P2Y12 and Aspirin reaction units pre and post colchicine 0.5mg twice daily oral dose. |
Countries
Trinidad and Tobago
Outcome results
None listed