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Comparison Between Serratus Anterior Plane Block and Erector Spinae Plane Block in Coarctectomy

Analgesic Effect of Ultrasound Guided Erector Spinae Plane Block Versus Serratus Anterior Plane Block in Pediatric Patients Undergoing Aortic Coarctectomy , a Randomized Controlled Study .

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06567275
Enrollment
28
Registered
2024-08-22
Start date
2024-08-24
Completion date
2025-04-15
Last updated
2025-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Coarctation

Keywords

erector spinae plane block, serratus anterior plane block, aortic coarctectomy

Brief summary

Pain is considered to be subjective, however, in children, it is believed to be felt rather than expressed because they often depend on the caregiver for their safety and well-being. There is significant pain after thoracotomy surgery because of pleural and muscular damage, ribcage disruption, and intercostal nerve damage during surgery, which if not effectively managed, will lead to various systemic complications; pulmonary (atelectasis, pneumonia, and stasis of bronchial secretions), cardiovascular (increased oxygen consumption and tachycardia), musculoskeletal (muscle weakness), increased neurohormonal response and prolonged hospital stay. So adequate and sufficient post-operative analgesia for pediatric patients is mandatory. The use of highly potent opioids for pediatric cardiothoracic anesthesia has gained widespread popularity during the last 20 years. In addition to the important advantage of hemodynamic stability, the large-dose opioid-based anesthetic techniques also blunt the stress response, However, large doses can cause oversedation, respiratory depression, and prolonged mechanical ventilation after surgery. serratus anterior plane block guided by ultrasound was developed by Blanco et al, it is a novel technique in the management of pain following thoracic procedures. Local anesthetic inserted into these planes will spread throughout the lateral chest wall, resulting in paresthesia of the T2 through T9 dermatomes of the anterolateral thorax. It became popular because it is much safer and easily administered than other alternative regional techniques such as thoracic paravertebral and thoracic epidural blocks. The Erector Spinae Plane Block (ESPB) is also one of the recently known pain-controlling techniques used in pediatric cardiothoracic surgeries. It became popular because it is much safer and easily administered than other alternative regional techniques such as thoracic paravertebral and thoracic epidural blocks. Chin et al. documented the cadaveric spread of local anesthetic and noted that, radiologically, the local anesthetic spread extended 3 or 4 levels cranially and caudally from the site of injection. These two blocks have been compared in a study by wang HJ et al in patients undergoing radical mastectomy. To our knowledge, the comparison of serratus Plane Block versus erector spinae plane block in aortic coarctectomy operations in pediatric patients has not been investigated yet. This has encouraged the performance of the present study.

Interventions

PROCEDUREErector Spinae Plane Block

Ultrasound-guided erector spinae plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

PROCEDURESerratus Anterior Plane Block

Ultrasound-guided serratus anterior plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
3 Months to 2 Years
Healthy volunteers
Yes

Inclusion criteria

* Age: 3 months-2 years. * RACHS-1 score 3. * Patients undergoing aortic coarctectomy operation with Lateral thoracotomy incision.

Exclusion criteria

* Patients whose parents or legal guardians refuse to participate. * Preoperative mechanical ventilation. * Preoperative inotropic drug infusion. * Perioperative cardiopulmonary arrested patients. * Patients undergoing aortic coarctectomy operation with midline sternotomy incision. * History of mental retardation or delayed development that may interfere with pain intensity assessment. * Known or suspected coagulopathy. (PT \< 75% of control) * Any congenital anomalies or any infection at the site of injection. * Known or suspected allergy to any of the studied drugs. * liver enzymes elevated more than the normal values. * Renal function impairment (Creatinine value more than 1.2mg/dl or BUN more than 20mg/dl). * Heart failure patients * Redo patients and previous catheter dilatations

Design outcomes

Primary

MeasureTime frameDescription
Total intraoperative fentanyl consumption by mcg/kg.Intra-operatively up to extubationcalculating the total dose of fentanyl used intraoperatively

Secondary

MeasureTime frameDescription
Time (in minutes) to 1st rescue analgesia (morphine)1st 24 hours postoperativelyestimating the time of the need for 1st dose of morphine which was given for pain scores ≥ 4
Heart rate and systolic blood pressureup to 15 minutes after extubationrecorded at 5 minutes after intubation (baseline value), before skin incision at 15 minutes after the block, after skin incision, after rib retraction, after aortic clamping, after aortic declamping, immediately after skin closure, and at 15 minutes after extubation
The need and the dose of sodium nitroprusside after aortic clampingfrom aortic clamping until removal of the clampssodium nitroprusside was given to control the hypertensive response to aortic clamping
total morphine doseup to 24 hours after surgerymorphine was given for pain scores ≥ 4
Face, Legs, Activity, Cry, Consolability (FLACC) scoreup to 24 hours after surgeryPostoperative pain was assessed using the Face, Legs, Activity, Cry, Consolability (FLACC) score every 2 hours for the first 24 hours postoperatively. If the FLACC score ≥ 4, 0.02 mg/kg morphine IV was administered as rescue analgesia to be repeated every 15-20 minutes till the pain score reaches \< 4, not exceeding 0.2 mg/kg every 6 hours

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026