Heart Failure
Conditions
Brief summary
This observational study involves ADHF patients at two sites in the United States and Germany. After informed consent and screening assessments, participants will perform daily voice recordings during their hospital stay, from admission until discharge. Alongside voice data, additional clinical information such as left ventricular ejection fraction, NTpro-BNP levels, and ECG-data will be collected for comprehensive analysis. The study's goal is to identify voice-based indicators of heart failure progression, with the potential to enhance remote monitoring and self-management strategies for heart failure patients.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Mayo Clinic
Noah Labs
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinically diagnosed with Acutely Decompensated Heart Failure. * At least 18 years of age.
Exclusion criteria
* Disabling mental diseases (e.g., Alzheimer's disease) * Clinically diagnosed chronic obstructive pulmonary disease (COPD) * Treatment in ICU or IMU * Dialysis treatment * Previous operations on organs involved in generation of voice (vocal tract, vocal folds, etc.) * Neurodegenerative diseases * Pregnancy * Inability to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in vocal characteristics from admission to discharge and their correlation with heart failure severity markers. | Hospital stay | The primary endpoint is the change in vocal characteristics from admission to discharge, and its correlation with clinical markers of heart failure severity, such as weight change from admission to discharge, NTpro-BNP levels, ECG-parameters, and left ventricular ejection fraction (LVEF). |
Countries
Germany, United States
Contacts
Primary ContactLeonhard Riehle, MD
Outcome results
None listed