Anorexia Nervosa, Bulimia Nervosa
Conditions
Brief summary
The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 78 women with an eating disorder (26 with anorexia nervosa \[AN\], 26 with bulimia nervosa \[BN\]) and 26 healthy controls (HC) aged 18-39. Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms. Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms. Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.
Interventions
None listed
Sponsors
University of California, San Diego
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
Eating Disorder Group: * Between the ages of 18 and 39 years old * Meet DSM-V criteria for anorexia nervosa or bulimia nervosa Healthy Controls: * Between the ages of 18 and 39 years old * Have maintained 85% to 120% ideal body weight since menarche
Exclusion criteria
* Psychotic illness/other mental illness requiring hospitalization * Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures. * Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight * Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness * Any contraindication to undergoing an MRI * Primary obsessive compulsive disorder or primary major depressive disorder Additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Learning rate | 25 minutes | Behavioral responses during a card game gambling task |
| fMRI brain response | 25 minutes | fMRI brain activity associated with the card game gambling task |
| Brain connectivity | 10 minutes | Whole-brain functional connectivity associated with the card game gambling task |
Countries
United States
Contacts
CONTACTChristina E Wierenga, PhD
Outcome results
None listed