Congenital Heart Disease
Conditions
Brief summary
The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise.
Interventions
PROCEDURECardiac Cath
Patient will undergo standard of care Cardiac Cath and in addition invasive CPET (Cardiopulmonary exercise testing) will be performed during the procedure.
Sponsors
Mayo Clinic
National Heart, Lung, and Blood Institute (NHLBI)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Congenital Heart Disease Diagnosis * Undergoing Clinically indicated Cardiac Cath
Exclusion criteria
* Unable to consent * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in left ventricular end-systolic elastance from rest to peak exercise | Baseline | Change in left ventricular end-systolic elastance will be measured in ΔmmHg/mL |
| Change in Left ventricular cardiac output from rest to peak exercise | Baseline | Change in left ventricular cardiac output will be measured in ΔL/min |
| Change in systemic vascular resistance from rest to peak exercise | Baseline | Change in systemic vascular resistance will be measured in ΔWoods Units |
| Change in right ventricular free-wall strain from rest to peak exercise | Baseline | Change in right ventricular free-wall strain will be measured in Δ% |
| Change in right ventricular cardiac output from rest to peak exercise | Baseline | Change in right ventricular cardiac output will be measured in ΔL/min |
| Change in pulmonary vascular resistance from rest to peak exercise | Baseline | Change in pulmonary vascular resistance will be measured in ΔWoods Units |
Countries
United States
Contacts
CONTACTACHD Research Program
PRINCIPAL_INVESTIGATORAlexander Egbe, M.B.B.S., M.P.H.
Mayo Clinic
Outcome results
None listed