Facial Scars
Conditions
Brief summary
Most of the body's tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. The scars widen when the overlying musculature pulls apart suture lines. Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis. Also, mesotherapy is the non-invasive transdermal injection which can aid the skin to increase collagen and elastin production. Thus, both techniques are eligible for enhancement of facial scars.
Interventions
OTHERBotulinum Toxin Type A
Patients will receive BTA injection within a period of 5 days after primary closure.
OTHERMesotherapy
Patients will receive mesotherapy growth factor serum with a derma pen within a period of 5 days after primary closure.
Sponsors
Hams Hamed Abdelrahman
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patient suffering from vertical or oblique forehead lacerations caused by trauma. * Recent and fresh wounds. * Atrophic scar (linear scar).
Exclusion criteria
* Infected wound. * Patient on chemotherapy treatment and history of malignancy. * Patients suffering from burns on the forehead or complicated lacerations. * Allergy to drugs used in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in scar appearance | Baseline, 1 month, 3 months, 6 months | The Vancouver Scar Scale (VSS) will be measured to calculate scar appearance. The VSS evaluates four indicators: vascularity, pigmentation, pliability, and height. It has a score ranging from 0-13. * Vascularity: Normal 0, Pink 1, Red 2, Purple 3 * Pigmentation: Normal 0, Hypopigmentation 1, Hyperpigmentation 2 * Pliability: Normal 0, Supple 1, Yielding 2, Firm 3, Ropes 4, Contracture 5 * Height: Flat (0), \< 2 mm (1), 2-5 mm (2), \> 5 mm (3) |
| Change in wound width | Baseline, 1 month, 3 months, 6 months | The mean wound width will be measured using a graduated Vernier caliper |
Countries
Egypt
Outcome results
None listed