Healthy
Conditions
Keywords
Functional Magnetic Resonance Imaging (fMRI), High-density transcranial direct current stimulation, manual dexterity, Non-invasive brain stimulation
Brief summary
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS. The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
Detailed description
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
Interventions
DEVICEStandard HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
DEVICEMultifocal network targeted HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
DEVICEFunctional Magnetic Resonance Imaging (fMRI)
Participants will have an MRI before or after having HD-tDCS intervention.
Sponsors
University of Michigan
Medical University of South Carolina
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
Participants will be randomized and counterbalanced to arm 1 or arm 2.
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants should be in good health with normal or corrected-to-normal visual acuity * Right handed * No history of neurological disorder * English speaker * Able to provide written consent prior to admission
Exclusion criteria
* Left-handed * Participants are pregnant, suspect pregnancy or are attempting to become pregnant * Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump * Have cochlear hearing implants * Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol) * Have non removable body piercings or have foreign objects in body * Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol) * Have a personal or family history of seizure/epilepsy * Taking prescription drugs that lower the threshold for seizures * Recent history of excessive alcohol consumption * History of alcohol addiction/dependence * Recent history of recreational drug use * History of drug addiction/dependence * Recent history of recreational drug use * History of drug addiction/dependence * Diagnosed with a stroke, brain hemorrhage, brain tumor, encephalitis. * Diagnosed with multiple sclerosis * Diagnosed with Parkinson's disease or Alzheimer's disease * Diagnosed with depression in the past 6 months * Diagnosed with attention deficit disorder, schizophrenia, manic depressive (bipolar) disorder * Diagnosed with normal pressure hydrocephalus or increased intra-cranial pressure * Diabetes requiring insulin treatment * Any serious heart disorder or liver disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent change in precision force-tracking task | Baseline and 24 hours after the third sessions are completed | Squared distance (error) from the cursor to the target in precision force-tracking task, estimated as the root mean squared error (RMSE). |
| Percentage change in the time to complete the nine-hole peg test (9-HPT) | Baseline and 24 hours after the third sessions are completed | 9-hole peg test is a manual dexterity measure, estimated as the time required to complete the task (seconds). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage change in the mean choice reaction time | Baseline and 24 hours after the third sessions are completed | Mean reaction time for subjects responding in the 2-choice reaction time control task, for correct responses |
Countries
United States
Contacts
CONTACTMichael Vesia, PhD
PRINCIPAL_INVESTIGATORMichael Vesia, PhD
University of Michigan
Outcome results
None listed