Post Partum Hemorrhage
Conditions
Brief summary
Controlling hemorrhage during and after a cesarean section reduces significantly maternal mortality and morbidity and the present study is important for detection of the effectiveness of routinely increasing the oxytocin dose instead of using the standard dose only in preventing postpartum hemorrhage and additional use of uterotonics in the first 24 hours after cesarean section for high risk pregnancy.
Interventions
DRUGOxytocin
will receive 10 IU oxytocin intravenous bolus over one min and infusion of 10 IU oxytocin in 500 ml of 0.9 saline over four hours.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* \- Medical disorders ie: Hypertensive diseases with pregnancy - Diabetes Mellitus - Collagen diseases - Coagulopathies - Cardiac diseases - Anemia * History of postpartum hemorrhage * Placental disorders ie: placenta previa * Infertility and ICSI * High Parity * History of Endometriosis * Fetal disorders (IUGR, IUFD, Preterm, Congenital anomalies, oligohydramnios or polyhydramnios, macrosomia) * Preterm labor on uterine relaxants * Twins pregnancy * Patients on antiplatelets and anticoagulants * Uneventful antenatal care
Exclusion criteria
* \- Oxytocin Allergy * Normal uncomplicated pregnancy * Emergency cesarean section * Exhausted uterus due to trial of normal labor * Couvelaire uterus
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood loss | at the end of the operation | measure blood in suction, towels and pads |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| haemoglobin | immediate preoperative | by laboratory asessment |
Outcome results
None listed