Volumetric Quantification of Epicardial Fat Using Semiautomated High Resolution Atrial CT Segmentation in Patients With Atrial Fibrillation Receiving Catheter Ablation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06559787

Acronym

AFAT

Enrollment

200

Registered

2024-08-19

Start date

2022-08-18

Completion date

2025-06-30

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Keywords

epicardial fal

Brief summary

The goal of this prospective observational study is to learn about the influence of epicardial fat on the success of catheter ablation in patients with atrial fibrillation.

Detailed description

A volumetric quantification of epicardial fat is examined by dual source cardiac computet tomography in patients with paroxysmal or persistent atrial fibrillation prior to receiving their first catheter ablation for atrial fibrillation. After ablation the recurrence of arrhythmia is examined after 3 and 6 months respectively.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients with planned catheter ablation due to paroxysmal or persistent atrial fibrillation * written informed consent * planned computet tomography

Exclusion criteria

* history of left atrial catheter ablation * minor patients or patients not capable of giving written informed consent * contraindication for computet tomography with contrast agents (e.g. allergy to contrast agents or relevant renal insufficiency or hyperthyreosis) * patients with congenital heart defects or history of cardial surgery

Design outcomes

Primary

Measure	Time frame	Description
Influence of epicardial adipose tissue (EAT) volume on 1 year arrhythmia recurrences after catheter ablation	measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months	influence of EAT volume quantified by volumetric CT segmentation on 1 year arrhythmia recurrences after catheter ablation for paraxysmal or persistent atrial fibrillation

Secondary

Measure	Time frame	Description
associations between EAT and gender, BMI, cholesterol levels, body fat	measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months	associations between EAT and gender, BMI, cholesterol levels, body fat
associations between EAT and left atrial wall thining	measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months	associations between EAT and left atrial wall thining
associations between EAT and low voltage areas quantified by high density electroanatomical mapping	measurement of epicardial fat and catheter ablation at baseline	associations between EAT and low voltage areas quantified by high density electroanatomical mapping

Countries

Germany

Outcome results