Hepatocellular Carcinoma Stage III
Conditions
Keywords
Hepatocellular Carcinoma, Prognosis, Imaging, Gross classification
Brief summary
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor with significant differences in invasion, proliferation ability and patient prognosis. Currently, there is a lack of non-invasive and simple indicators to predict the prognosis of HCC patients and assist clinical decision-making. The identification of HCC macroscopic or histopathological classification requires large pathological specimens obtained through surgical resection, but only about 20% of patients are eligible for surgical treatment. Moreover, most liver cancer diagnoses can be confirmed by imaging examinations without relying on pathological results. For patients who have not undergone surgical resection, the lack of histopathological information during treatment means that there is no basis for judging tumor proliferation and obtaining rich prognostic information. Therefore, evaluating the invasion and proliferation ability of HCC based on macroscopic imaging assessment has important implications for guiding individualized diagnosis and treatment throughout the entire process including surgical strategy guidance, local treatment selection, systemic therapy planning as well as patient follow-up and prognosis evaluation. Ultrasound and MRI are ideal entry points as first-line imaging methods for liver cancer diagnosis. This study aims to evaluate HCC macroscopic or histopathological classification based on multimodal imaging (ultrasound, CT, MRI), thereby assessing its invasion and proliferation ability which has important implications for guiding individualized diagnosis and treatment throughout the entire process including surgical strategy guidance, local treatment selection, systemic therapy planning as well as patient follow-up and prognosis evaluation. By analyzing macroscopic image features we aim to explore their cross-scale correlations with HCC macroscopic classification,histopathological classification,and gene molecular typing.
Interventions
PROCEDUREHepatectomy
According to guideline recommended procedure of hepatectomy
Sponsors
The First Hospital of Jilin University
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* According to the WHO classification, the pathological diagnosis is hepatocellular carcinoma. * The initial treatment is curative-intent hepatectomy. * There is no evidence of major vascular/hepatic portal invasion, extrahepatic/lymph node metastasis, or other malignant tumors. * Age 18-80 years old.
Exclusion criteria
· Not meeting any one of the inclusion criteria or being unwilling/unable to follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | through study completion, an average of 1 year | OS was defined as death related to any cause and was indexed from the date of ablation or surgery until last contact or death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease-free survival | through study completion, an average of 1 year | DFS was defined as the time interval between first treatment and recurrence or death, whichever occurred earlier |
| Imaging features | through study completion, an average of 1 year | MRI or ultrasound Imaging features of the four types |
| Quantification of immune cells of the resected liver tumour | through study completion, an average of 1 year | Quantification of immune cells of the resected liver tumour using HE staining and immunohistological staining to assess molecular marker and cell infiltration in tumor and liver parenchyma |
| mRNA sequencing data of the resected liver tumour and peritumor parenchyma | through study completion, an average of 1 year | mRNA sequencing data of the resected liver tumour and peritumor parenchyma specimen to assess the gene enrichment |
Countries
China
Contacts
Primary ContactChuan Pang
Outcome results
None listed