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The Internal Prospective Validation of the Cancer Admission Score (CAS) Prediction Model

The Internal Prospective validatiON of a prediCtiOn Model for the Change of admIssion for Patient With caNcer Admitted to the emerGency Department (ONCOMING Study)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06558487
Acronym
ONCOMING
Enrollment
200
Registered
2024-08-16
Start date
2024-12-02
Completion date
2025-12-31
Last updated
2025-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oncology

Keywords

cancer care, emergency care, prediction model, admission

Brief summary

The goal of this single center prospective observational study is to determine the agreement between the cancer admission score (CAS) predicted disposition and the actual disposition in patients with an active cancer diagnosis visiting the emergency department (ED). The main question it aims to answer are: Is the performance of the CAS good enough to play a potential role in the ED care process. For each participant the CAS will be calculated and compared to the actual outcome.

Detailed description

The goal of this single center prospective observational study is to determine the agreement between the cancer admission score (CAS) predicted disposition and the actual disposition in patients with an active cancer diagnosis visiting the emergency department (ED). The main question it aims to answer are: Is the performance of the CAS good enough to play a potential role in the ED care process. The first part of this study is an observational part. For patients with cancer that are presented to the emergency department (ED) the cancer admission score (CAS) will be calculated by the model both after triage and after the first blood results are in. Furthermore, the expected disposition will be asked to the attending nurse after triage and after the first blood results. Finally, the actual disposition will be written down after the patient has left the ED, in combination with ED length of stay (LOS) and the time for the attending physician to reach a decision about the disposition (time-to-disposition) and the time for a patient to leave the ED (time-to-leave). The second part is the interventional part. In this part we introduce an early bed reservation intervention. The CAS is still calculated for the patient. If the CAS is 80% or higher based on the triage, the attending physician will be alerted and a call to the bed coordinator will be placed to reserve a bed in advance. After the first blood results are known the second CAS will be calculated, if this drops below 70% the reserved bed can be canceled by the attending physician. Similar to the first part, the expected disposition from the attending nurse after triage and after first blood results will be collected. Finally, the actual disposition, ED LOS, time-to-disposition and time-to-leave will be noted.

Interventions

OTHERCancer Admission Score Prediction Model

A prediction model that calculates the chance for a patient to be admitted after triage and after first blood results

Sponsors

Erasmus Medical Center
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients with solid or hematological malignancies and receiving systemic therapy or having received systemic therapy within the last 3 months. * Presented at or admitted from the emergency department for the oncology, hematology neuro- or lung-oncology clinical unit.

Exclusion criteria

* \<18 years old * Only received a surgical intervention as cancer treatment * Admitted to the ED for the surgical department

Design outcomes

Primary

MeasureTime frameDescription
Cancer Admission ScoreThrough study completion, an average of 6 monthsCancer Admission Score (CAS) calculated after triage and after first blood results, ranging from 0 to 100%. The higher the score the greater the change of admission
Agreement between the CAS and the actual dispositionThrough study completion, an average of 6 monthsAgreement between the CAS predicted outcome and the actual outcome
DispositionThrough study completion, an average of 6 monthsThe outcome of a visit to the ED, being either admission or home

Secondary

MeasureTime frameDescription
Agreement between expected disposition by nurse and actual dispositionThrough study completion, an average of 6 monthsAgreement between the nurse predicted outcome and the actual outcome
time-to-dispositionThrough study completion, an average of 6 monthsThe average time between patient's arrival at the emergency department (ED) and the decision to disposition
time-to-leaveThrough study completion, an average of 6 monthsThe average time between the decision to disposition and departure from the ED (either home or ward)
ED Length of StayThrough study completion, an average of 6 monthsThe total time spent in the ED by a patient during their visit

Other

MeasureTime frameDescription
SexThrough study completion, an average of 6 monthsThe sex of a patient
Type of TreatmentThrough study completion, an average of 6 monthsType of cancer treatment a patient receives
Type of CancerThrough study completion, an average of 6 monthsThe type of cancer a patient has
AgeThrough study completion, an average of 6 monthsThe age of a patient
Main ComplaintThrough study completion, an average of 6 monthsMain complaint of ED visit
Physical parameters recorded during triageThrough study completion, an average of 6 monthsPhysical parameters that are recorded during triage and are used in the prediction model
First Blood resultsThrough study completion, an average of 6 monthsThe blood results that are recorded during triage and are used in the prediction model

Countries

Netherlands

Contacts

Primary ContactJason den Duijn
j.denduijn@erasmusmc.nl0107040704

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026