Acute Bronchiolitis
Conditions
Keywords
Bronchiolitis, 3% hypertonic saline
Brief summary
This study aims to determine the efficacy of nebulising 3% hypertonic saline in improving clinical symptoms and reducing the length of hospital stay in infants with acute bronchiolitis.
Detailed description
Bronchiolitis is the most prevalent disease in infants, especially children younger than two years old. Clinical manifestations vary from mild to severe, even life-threatening respiratory failure. Airway oedema and mucus plugging are the principal pathological features in infants with acute bronchiolitis. Nebulising 3% hypertonic saline solution may reduce these pathological changes, but the evidence remains equivocal.
Interventions
4ml nebulized three times daily
OTHERStandard care
Standard care
Sponsors
Can Tho University of Medicine and Pharmacy
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A randomized controlled open-label parallel-arm clinical trial, with allocation 1:1, was conducted to investigate whether nebulizing 3% hypertonic saline will improve clinical symptoms and reduce the length of hospital stay in bronchiolitis compared with the control group.
Eligibility
Sex/Gender
ALL
Age
1 Months to 24 Months
Healthy volunteers
No
Inclusion criteria
* Pediatric patients diagnosed with acute bronchiolitis from 1 to 24 months old at Can Tho Children's Hospital.
Exclusion criteria
* Family members do not agree to let the child participate in the study. * Severe respiratory failure required mechanical ventilation. * The patient left on his own during treatment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improve clinical severity score after three days of treatment with nebulized 3% hypertonic saline. | three days | The clinical severity score is a validated, self-reported instrument assessing clinical severity over treatment. Possible scores range from 0 (mild) to 12 (severity). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Shorten the mean length of hospital stays in infants with bronchiolitis after treatment with nebulized 3% hypertonic saline. | From admission to discharge, up to 14 days | The mean length of hospital stays is the days from admission to discharge of all participants. |
Countries
Vietnam
Outcome results
None listed