Alcohol Withdrawal Syndrome
Conditions
Keywords
prediction, intensive care unit
Brief summary
alcohol use disorder (AUD) is a very common condition in patients admitting in ICU's. Brutal stop of alcohol consumption may lead to a withdrawal syndrome, wich is associated with a worse outcome for ICU patients (longuer ICU and hospital stays, use of mechanical ventilation, traumas). The aim of this study is to valid a score (PAWSS : prediction of alcohol withdrawal syndrome (AWS) scale) to predict at admission mild to severe AWS in ICU patients population.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* more than 18 years old * able to answer to PAWSS in the first 48hours of ICU stay
Exclusion criteria
* No alcohol consumption in the last 30 days * hospital stay of more than 5 days at ICU admission * hospital stay less than 5 days in total * expected sedation time of more than 48h * patient not able to understand the PAWSS * no consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of PAWSS statistic performances to predict AWS in ICU patients | the first 5 days of hospital stay | Evaluation of sensitivity, specificity, positive and negative predictive values of PAWSS to predict moderate or severe AWS (defined by a CIWA greater than or equal to 8) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Creation of a new score, the PAWSS-ICU, able to predict AWS in ICU patients | during ICU stay | To this end, the characteristics of the \[no weaning/minimal weaning\] and \[moderate weaning/severe weaning\] groups will be compared, in order to identify significant differences between these two groups, and thus enable the creation of a new score. On an exploratory basis : * assess the incidence of alcohol misuse and withdrawal syndrome in our population, * assess the incidence of complications in the population with moderate to severe withdrawal (trauma, occurrence of pneumopathy, need for mechanical ventilation), * assess length of hospital stay and in-hospital mortality. Translated with DeepL.com (free version) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of alcohol use disorders (AUD) ans AWS in our population | during ICU stay | AUD definition for our study : * AUD is mentionned in patient's medical record * heavy alcohol use (more than 3 drinks a day for a men ant more than 2 drinks a day for a woman) * harmful use : physical or psychological complications of alcohol use (liver cirrhosis, depression, ...) |
Countries
France
Outcome results
None listed