Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

Acute Effects of Supplemental Oxygen on Memory in Healthy Older Adults: a Double-Blind Within-Subject Crossover Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06555484

Enrollment

Registered

2024-08-15

Start date

2024-05-28

Completion date

2024-10-31

Last updated

2025-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognition

Keywords

Oxygen Concentrator, Hyperoxia

Brief summary

Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.

Detailed description

Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).

Interventions

DEVICECross Over Assignment Supplemental Oxygen and Supplemental Air

Subjects repeatedly complete memory tests, either first while breathing supplemental oxygen or first while breathing supplemental air (in an order randomly assigned).

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

Acute effects of oxygen on memory testing in healthy adult volunteers

Eligibility

Sex/Gender

ALL

Age

22 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Subjects are intended to represent healthy adults. Patients will include a mix of self-reported gender and ethnic/racial identification. 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Adult (aged 22+)

Exclusion criteria

* Patients who self-report diagnosis of respiratory-related conditions will be excluded. * Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.

Design outcomes

Primary

Measure	Time frame	Description
2 back Memory test performance	At baseline and 5 mins post-intervention exposure	\# correct on 2-back test
Memory test performance	At baseline and 5 mins post-intervention exposure	New Medical Icons Spatial Test

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026