Sedation, Total Knee Arthroplasty
Conditions
Brief summary
Dexmedetomidine is often used for sedation procedures. It has also been shown to have a pain-protective effect. Researchers predicted that using dexmedetomidine for sedation in total knee arthroplasties performed under spinal anesthesia would reduce the frequency of rebound pain and pain scores.
Detailed description
Randomization will take place before the patient enters the operating room. After spinal anesthesia is applied, 0.4 mcg/kg sedadomide loading will be done for 10 minutes in the sedation group, and then 0.4 mcg/kg/h sedadomide infusion will continue until the end of the surgery. Patients selected for the control group will be given the same amounts of saline. At the end of the surgical procedure, saline and sedadomide infusions will be stopped. All patients will undergo an adductor canal block under USG guidance in the recovery room. 50 mg of buvacin will be given to the block area. Patients will be fitted with a patient control analgesia device, which only provides bolus application and provides 20 mg of madol in each bolus. Postoperatively, sudden onset severe withdrawal pain outside the normal course of pain starting within 48 hours will be followed and Vas-bromage monitoring will be done at 0, 1, 2, 4, 8, 12, 24, 36, 48 hours.
Interventions
DRUGDexmedetomidine
Patient group to be given dexmedetomidine
DRUGSaline
Patient group to be given salin
Sponsors
Ankara City Hospital Bilkent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Total Knee arthroplasty American Society of Anesthesiologist score of 1-3 Age 18-85 Elective total knee arthroplasty under spinal anesthetic.
Exclusion criteria
* Situations in which spinal anesthesia is contraindicated * Advanced organ failure states(cardiac,hepatic,respiratuar or renal) * Pregnancy * BMI \> 40 kg/m\^2 * Do not want to participate in the study * Younger than 18 or older than 85 * Have bilateral total knee arthroplasty or resurgery * Develop an unexpected intraoperative surgical complication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rebound pain VAS scores and incidence of rebound pain | 48 hours after surgery | Rebound pain-defined as transient acute postoperative pain within 12-24hrs that ensues following resolution of sensory blocked. |
Countries
Turkey (Türkiye)
Outcome results
None listed