Early Postoperative Atelectasis
Conditions
Brief summary
This study aims to explore the clinical effect of THRIVE in improving early postoperative atelectasis in patients undergoing long-term non-intubated anesthesia gastrointestinal endoscopy.
Interventions
PROCEDURETransnasal humidified rapid insufflation ventilatory exchange（THRIVE）
Transnasal humidified rapid insufflation ventilatory exchange（THRIVE）
PROCEDUREconventional oxygen mask
conventional oxygen mask
Sponsors
Northern Jiangsu People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Multiple polyps resection, ESD(Endoscopic Submucosal Dissection) , EMR(Endoscopic Mucosal Resection), enteroscopy and other gastrointestinal endoscopic diagnosis and treatment were performed 2. The duration of anesthesia is more than 30 minutes, that is, from induction to withdrawal of anesthesia 3. ASA(American Society of Anesthesiologists) ≤ II 4.18kg/m2\<BMI\<30 kg/m2 5.Informed consent, voluntary participation in the experiment, and signed by the subject informed consent
Exclusion criteria
1. ASA classification ≥ III; 2. History of previous lung or nasal surgery; 3. History of chronic obstructive pulmonary disease (COPD) or restrictive lung disease; 4. History of obstructive sleep apnea syndrome; 5. History of upper airway obstruction; 6. History of head and neck radiation therapy; 7. Significant nasal septum deviation; 8. Active infection (defined as a white blood cell count \>10\*10\^9 or a body temperature \>38°C); 9. Gastrointestinal perforation; 10. Combined use of other anesthetic methods or inhalation anesthetics outside of non-intubated intravenous anesthesia; 11. Concurrent other medical procedures besides the prescribed gastrointestinal endoscopic procedures, such as ERCP(Endoscopic Retrograde Cholangiopancreatography); 12. Severe communication disorders due to conditions like severe hearing impairment or dementia; 13. Disagreement with participation in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of atelectasis | Early postoperative period | Lung ultrasound examination was performed before anesthesia induction (T1) and immediately after surgery (T2), and patients' modified lung ultrasound score (LUSS) was recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate (HR) | Baseline，during surgery and arrived at PACU | Throughout the procedure, the heart rate (HR) was continuously monitored. |
| Pulse oxygen saturation (SpO2) | Baseline，during surgery and arrived at PACU | Throughout the procedure, the pulse oxygen saturation (SpO2) were continuously monitored. |
| Mean blood pressure (MBP) | Baseline，during surgery and arrived at PACU | Throughout the procedure, the mean blood pressure (MBP) was measured at 3-minute intervals. |
| Patient satisfaction levels | After the patient is awake | The patients express their satisfaction with procedures on a numerical rating scale, ranging from 0 to 10, where 0 is the minimum and 10 is the maximum satisfaction level. |
| Endoscopist satisfaction levels | After the surgery | The Endoscopists express their satisfaction with procedures on a numerical rating scale, ranging from 0 to 10, where 0 is the minimum and 10 is the maximum satisfaction level. |
| Diaphragm movement | Before anesthesia induction (T1) and immediately after surgery (T2) | — |
| Adverse Events (AEs) Within 7 Days Post-Operatively | Within 7 days after surgery | Fever; Cough and Sputum Production; Antibiotic Usage |
| PACU Stay Duration | The time from entering PACU to improving Aldrete score ≥9 | — |
| Length of Hospital Stay | The time from admission to discharge | — |
| Dosage of propofol | During surgery | — |
| Dosage of remifentanil | During surgery | — |
| Adverse Events (AEs) During Surgery and PACU | During surgery and PACU | radycardia; Hypertension; Hypotension; Hypoxemia; Aspiration and Regurgitation |
Countries
China
Outcome results
None listed