Knee Osteoarthritis
Conditions
Brief summary
In the previous study Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113), we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.
Interventions
DEVICEMicro-Western Array
The subjects first took the energy measurement of the pulse sphygmograph and Ryodoraku, rested for 20 minutes, and then repeated the measurements again. In order to comply with the acupuncture treatment course was 5 weeks in the previous study, we have two blood draw point. Each subject's blood was drawn for the first time, and then for the second time in 5 weeks later. Each subject drew 10ml of blood each time. The blood samples are analyzed by Micro-Western Array (MWA) and Enzyme-linked immunosorbent assay (ELISA) to obtain the serum protein content value of healthy individuals.
Sponsors
China Medical University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults over 50 years old without knee pain
Exclusion criteria
1. Clinical diagnosis of knee osteoarthritis 2. Taking anti-inflammatory and analgesic drugs in the past month 3. Taking blood-lipid-lowering drugs or health foods in the past month 4. Received any acupuncture treatment in the past 3 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Micro-Western Array and Enzyme-linked immunosorbent assay | the first and the fifth weeks | Obtaining the serum protein content value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pulse sphygmograph and Ryodoraku | the first and the fifth weeks | the energy measurement of pulse and meridians |
Countries
Taiwan
Contacts
Primary ContactWan-Zhen Yu
Backup ContactYu-Chen Lee
Outcome results
None listed