Arthritis, Central Sensitisation, Postoperative Pain
Conditions
Brief summary
The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery. The aim of this study is to evaluate whether there is a difference in preoperative and postoperative pain and functional status between patients with and without central sensitization with knee osteoarthritis. When the literature was reviewed, it was seen that central sensitization was one of the important mechanisms that caused pain in knee osteoarthritis, and it was determined that this had negative consequences in terms of postoperative pain and improvement in functional status. In this study, the effect of central sensitization on the results will be investigated by evaluating pain and functional status before and after knee total joint prosthesis in two groups of knee osteoarthritis patients, with and without central sensitization, and by comparing the groups.
Interventions
PROCEDURETotal knee arthroplasty
Patients already admitted for total knee arthroplasty for knee osteoarthritis will have the procedure as planned
Sponsors
Istanbul University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of primary knee osteoarthritis * Planning for total joint replacement surgery for the knee * Being between the ages of 60-75
Exclusion criteria
* Having secondary knee osteoarthritis * Planning for knee total joint prosthesis revision * Having uncontrolled systemic disease (such as diabetes mellitus, hypertension, thyroid disease) * Having neuromuscular disease * Having a body mass index over 40
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Knee pain | Preoperative, 1 month postoperative and 3 months postoperative | Knee pain will be assessed with numerical rating scale, where the patients rate their pain on a scale from 0 to 10 where 0 means no pain and 10 means the most severe pain they can imagine. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Status | Preoperative, 1 month postoperative and 3 months postoperative | Functionality of the patients will be assessed with WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index). Responses are typically rated on a scale from 0 (none) to 4 (extreme). Higher scores indicate greater impairment. |
Contacts
Primary ContactFatma Merih Akpınar
Backup ContactBerk Korkut
Outcome results
None listed