Bowel Preparation
Conditions
Keywords
bowel preparation, compound polyethylene glycol electrolyte powder, bowel preparation quality, comfort, tolerability
Brief summary
The goal of this quasi-experimental study was to compare the effect of single-dose and split-dose 3L compound polyethylene glycol electrolyte powder (PEG) regimen on the quality, comfort and tolerability of bowel preparation in patients who would undergo colonoscopy examination or treatment. Participants in group A received a split-dose 3L PEG regimen, with 1L PEG taken on the night before the colonoscopy and 2L PEG taken 4-6 hours before the procedure. Participants in group B received a single-dose 3L PEG taken 4-6 hours before the colonoscopy.
Detailed description
Related guidelines recommend a split-dose method for bowel preparation. However, this regimen also has limitations, such as affect patients' sleep and that of other patients in the ward, and exacerbate their discomfort due to increased hunger. This quasi-experimental study aims to investigate the effect of single-dose and split-dose 3L compound polyethylene glycol electrolyte powder (PEG) regimen on the quality, comfort and tolerability of bowel preparation. A total of 101 patients scheduled for colonoscopy in two gastroenterology wards in a Chinese university hospital from January to June 2021 were enrolled in the study. Patients in one department (group A) were given the 3L PEG in two doses: 1L of PEG was taken from 8:00 pm to 9:00 pm on the night before the examination, and the remaining 2L of PEG were taken from 4:00 am to 6:00 am on the day of the examination, with 250 mL taken every 15 minutes until finished. Patients in the other department (group B) were given 3L of PEG in a single dose, which was taken gradually from around 3-4 am, 4-6 hours before the examination. Patients in group B were also instructed to take 250 mL every 15 minutes until the 3L were finished. The bowel preparation quality, comfort, sleep quality, adverse reactions, acceptance, and compliance were evaluated.
Interventions
PROCEDUREdifferent bowel preparation regime
Patients in Group B receive the 3L of PEG in a single dose
PROCEDUREtraditional bowel preparation regime
Patients in Group A receive the 3L of PEG in a split dose
Sponsors
Tongji Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* inpatients aged 18 to 70 years, with informed consent and willingness to cooperate
Exclusion criteria
* intestinal obstruction and stenosis; * a history of PEG allergy; * constipation or taking laxatives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bowel preparation quality | The BBPS scores were filled out by the treating physician in the designated area on the patient's examination request form and were collected and organized by the research team immediately after the end of the day's clinic | Bowel preparation quality was evaluated by the Boston Bowel Preparation Scale (BBPS) |
| comfort | Patients self-evaluated their comfort level during the bowel preparation process after it was completed | a self-designed comfort evaluation scale was used, with a linear visual analog rating scale ranging from 0 (comfortable) to 4 (extremely uncomfortable). |
| tolerability | Patients finished the tolerability evaluation by themselves after completing bowel preparation and before being sent to the endoscopy center | ①Patients self-assessed whether they were willing to undergo the same bowel preparation method again after the end of bowel preparation; ②Patients self-evaluated the difficulty of completing the bowel cleansing process after bowel preparation, with a score of very difficult (1 point), difficult (2 points), moderate (3 points), easy (4 points), and very easy (5 points) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sleep quality | Patients finished the sleep quality evaluation by themselves after completing bowel preparation and before being sent to the endoscopy center | Patients self-evaluated the quality of sleep on the night before bowel preparation, which is compared with usual and may be the same or slightly worse. |
| adherence | Patients finished the adherence evaluation by themselves after completing bowel preparation and before being sent to the endoscopy center | Patients' compliance with medication was evaluated based on three indicators: whether the patient started taking the medication at the correct time, whether the medication was taken completely according to the instructions, and whether the patient engaged in active exercise after taking the medication |
Countries
China
Outcome results
None listed