LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START IN IVF

IVF CYCLE SCHEDULING WITH LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START TO AVOID WEEKENDS RETRIEVALS: PROOF OF CONCEPT

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06551376

Enrollment

Registered

2024-08-13

Start date

2024-09-01

Completion date

2025-01-31

Last updated

2024-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IVF

Keywords

Ovarian Stimulation, luteal phase start, early follicular phase start, ovarian response

Brief summary

To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Detailed description

Objective To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles. Design Multicentric prospective non-randomized study Setting Two university-affiliated private assisted reproduction centers. Patient(s) Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled. Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria. Intervention(s) Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses; similarly, twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day. Main Outcome Measure(s) Primary outcome: number of mature oocytes retrieved. Secondary outcomes: fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate, and clinical pregnancy outcomes from FET cycles.

Interventions

OTHEROvarian Stimulation Start

To compare ovarian response accordin to ovarian stimualtion start

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled

Exclusion criteria

* Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were

Design outcomes

Primary

Measure	Time frame
mature oocytes retrieved	At retrieval

Secondary

Measure	Time frame
fertilization rate	24 hours after retrieval
viable embryo rate per oocyte retrieved	5 days after retrieval
cancellation rate	14 days after cycle start

Contacts

Primary ContactJorge Rodriguez-Purata, MD

jorge@ovulsans.com55 4246 9686

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026