Atopic Dermatitis
Conditions
Keywords
Atopic dermatitis, infant, Etology
Brief summary
Analysis of filmed sequences for the assessment of discomfort in atopic dermatitis in infants under 1year of age
Detailed description
Atopic Dermatitis (AD) is a chronic inflammatory and itchy dermatitis particularly common in childhood since it affects about 20% of the pediatric population, with revelation usually around the age of 3-6 months of life. However, there are very few pediatric population data on the prevalence of pruritus and associated discomfort in infants. Although the skin and the nervous system of the infant (\<6 months) are competent in the experiment of the pruritus, the acquisition of an intentional motricity allowing the targeted scratching of the affected body areas is done only from the age of 6 months, making it difficult to diagnose the intensity of the AD and assess the potential discomfort caused. Currently, the diagnosis and assessment of pruritus in children is based on a hetero-rating through scales, which are not at all applicable for infants under 6 months of age (population concerned by our study). The visual scale Numeric Rating Scale, validated in adult population seems to be the one that most accurately assesses the severity of pruritus. In pediatric populations, the use of the Eppendorf Itch Questionnaire and the US version of the Childhood Atopic Dermatitis Impact Scale are recommended. Alternatives to the clinical and subjective rating of the severity of pruritus have been described via actigraphy: thus, a strong statistical correlation has been demonstrated between a nocturnal measurement of wrist motor activity as a reflection of the intensity of pruritus, and the analysis of videos filmed in infra-red. But, again, the technique is not suitable for young infants, because of the absence of voluntary motivated motor skills, and because of less organized sleep / wake cycles. In order to better manage infants less than 1 year old, the analysis of their behavior in case of atopic dermatitis seems necessary to us to better identify a potential discomfort in these patients. This is an essential preliminary study that will allow us to better define the judgment criteria necessary for the implementation of an observational study comparing infants with atopic dermatitis to healthy infants.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Months to 1 Years
Inclusion criteria
* Infants under 1 year old * with atopic dermatitis * No opposition from at least one of the patient's parents
Exclusion criteria
* Acute intercurrent pathology * Severe malformation or genetic abnomalies * Parent (s) minor (s) or unfit (s) to give their informed consent * Refusal of patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Focal sampling and Scan sampling of the behaviors | 6 month | Frequency of behaviors observed by the method of focal sampling and scan sampling. All behavioral responses of the infants will be quantified from the video recordings. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of behaviors according to the severity of atopic dermatitis | 6 month | Frequency of focal sampling behaviors according to the severity of atopic dermatitis evaluated using SCORAD score All behavioral responses of the infants will be quantified from the video recordings. |
Countries
France
Outcome results
None listed