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Heat Acclimation in Females

The Cardiovascular, Hematological, and Performance Response to Heat Acclimation in Healthy Trained Females

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06551168
Enrollment
14
Registered
2024-08-13
Start date
2024-09-01
Completion date
2026-04-24
Last updated
2025-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Volume, Cardiac Output, Heat Exposure

Keywords

basic science

Brief summary

Heat acclimation is when you repeatedly exposure yourself to heat so that your body adapts and better tolerates heat. This project will determine if completing a heat acclimation maintenance period after heat acclimation is more beneficial than heat acclimating alone for exercise performance in the heat. To determine this, participants will exercise in the heat before heat acclimation, after heat acclimation, and after heat acclimation maintenance. Researchers will assess the heart's pumping capacity, blood volume, body temperature, and exercise performance to determine which approach is more effective.

Detailed description

Purpose and Hypothesis: Global warming combined with increased frequency of heat waves exposes those who are working, exercising, or competing outdoors to considerable thermal strain. Excessive heat stress decreases exercise performance and can lead to heat illnesses. Deliberate serial exposure to natural (acclimatization) or artificial (acclimation) heat (HA) is the most efficacious method to defend homeostasis at rest and during exercise in hot environments. Our project will determine if three weeks of heat acclimation maintenance (HAM) further potentiates exercise performance in the heat than exercise performance measured after 10 days of HA in females. Justification: Female participation in arduous occupations and professional sport is increasing. Presently a paucity of data regarding the female response to heat acclimation exist. Findings from this study will help females undertake effective and efficient strategies to mitigate thermal strain. Research design: This is an experimental trial with a treatment and a control group. VO2max, plasma volume (PV), core temperature, and cardiac output will be measured pre-, mid-, and post-intervention. Participants will complete 10 sessions of HA over two weeks. Participants will then undergo three weeks of HAM with three heat sessions per week. A heat performance test will be completed pre-, mid-, and post-intervention to examine performance changes. A control group will complete the same test schedule but will not perform any HA or HAM. Statistical analysis: Sample size will be 8 females in the experimental and 6 females in the control group. Data will be analyzed for normality using the Shapiro-Wilk test. Descriptive statistics will be presented as the mean and standard deviation. Statistical significance will be determined at P \<0.05. A two-way repeated measure ANOVA will be used to measure differences between groups and hemodynamic, cardiovascular and performance variable differences pre- and post-HA, and pre- post-HAM. If significant effects are present, these will be followed by a post-hoc Tukey's test. Pearson's r correlations (two-tailed) will be conducted between VO2max, and intravascular volumes and heat performance test outcome.

Interventions

OTHERHeat exposure

Participants will exercise at home while wearing a clothing ensemble over 19 one hour sessions. They will use validated perceptual scales to guide their effort and thermal sensation.

OTHERControl group

Participants will exercise at home over 19 one hour sessions. They will use heart rate to guide their effort. The exercise will take place in cool conditions

Sponsors

Trinity Western University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

The experimental group will undergo heat acclimation The control group will not undergo heat acclimation. The control group will undergo heart rate matched exercise of the same quantity but in a cool environment

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* Familiar with the sport of cycling and own a bicycle and smart trainer (or a trainer and a power meter). * Endurance athlete or currently engaging in endurance exercise * Maximal oxygen consumption (VO2max) greater than 40 ml/kg/min * Between the ages of 18 and 55 * Able to speak, read, and write in English

Exclusion criteria

* Unable to exercise * Previous or current heat intolerance * Pregnant

Design outcomes

Primary

MeasureTime frameDescription
Performance2 weeks and 5 weeksParticipants will complete a timetrial on a cycle ergometer in a heat chamber. Faster times following HA or HAM will be considered a marker of performance

Secondary

MeasureTime frameDescription
Intravascular volumes2 weeks and 5 weeksExpanded plasma volume or increased hemoglobin mass will be considered a positive response to heat acclimation

Countries

Canada

Contacts

Primary ContactAnita T Coté, PhD
anita.cote@twu.ca604.513.2121
Backup ContactNormand A Richard, MSc
nar11@sfu.ca604.513.2121

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026