Resectable Simultaneous Colorectal Cancer Liver Metastasis
Conditions
Brief summary
Simultaneous colorectal cancer liver metastasis (SCRLM) is one of the risk factors for poor prognosis in colorectal cancer. Surgical resection of primary and metastatic lesions is the first choice of treatment for patients with resectable SCRLM. Simultaneous resection of colorectal cancer liver metastases by totally open surgery (TOS) has been widely used. However, we propose that laparoscopic hybrid surgery (LHS) may have better short and long-term outcomes. This study aimed to compare the safety, short-term, and long-term efficacy of LHS versus TOS for patients with resectable SCRLMs.
Interventions
PROCEDURElaparoscopic hybrid surgery (LHS)
First performed the laparoscopic exploration of the entire abdominal-pelvic cavity to determine the resectability of the primary and metastatic lesions. After the blood vessel detachment and bowel detachment, the distal bowel of the tumor was severed and the pneumoperitoneum was closed. The liver metastases were then removed in both cohorts by open resection through the right subcostal incision.
Sponsors
Changhai Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Liver metastasis was detected while the colorectal cancer was diagnosed. * Both the primary lesions and liver metastases were confirmed by postoperative pathological examination. * Clinical data is complete.
Exclusion criteria
* Patients with unresectable extrahepatic metastases. * Patients with other malignant tumor diseases that have not been cured. * Clinical and pathological data were missed or incomplete follow-up data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| short-term outcome: Blood loss | Within one week of the patient undergoing surgery | Patient haemorrhage during surgery |
| short-term outcome: Postoperative hospital stay | Within one week of the patient undergoing surgery | Length of stay of patients after surgery |
| short-term outcome: Surgical complications | Within one week of the patient undergoing surgery | Complications that occur in patients after surgery |
| short-term outcome: Operative time | Within one week of the patient undergoing surgery | Time taken for surgery |
| short-term outcome: Time of liquid diet | Within one week of the patient undergoing surgery | Time for patients to eat fluids for the first time after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| disease-free survival (DFS) | 3years | the time after surgical treatment until the first observation of tumor recurrence or death for any reason |
| overall survival (OS) | 3years | the time after surgical treatment until death for any reason |
Countries
China
Outcome results
None listed