Breast Cancer
Conditions
Keywords
Internal mammary node irradiation, Node-positive breast cancer
Brief summary
The DBCG IMN study is a nationwide prospective population-based cohort study allocating node-positive breast cancer patients with right-sided tumors to internal mammary node irradiation (IMNI) and patients with left-sided tumors to no IMNI.
Interventions
RADIATIONInternal mammary node irradiation
Irradiation of the internal mammary nodes in intercostal space 1-4.
Sponsors
Danish Breast Cancer Cooperative Group
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with macrometastatic node-positive breast cancer treated with loco-regional radiotherapy.
Exclusion criteria
* Prior malignancies, bilateral breast cancer, neoadjuvant systemic therapy, recurrence before radiotherapy, and non-standard radiotherapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | 15-years. | Censored at end of study or by emigration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Breast cancer mortality | 15-years. | Censored at end of study or by emigration. |
| Distant recurrences | 15-years. | Censored at end of study or by emigration. Death by any cause was regarded as competing event. |
Outcome results
None listed