Carbon Monoxide Poisoning
Conditions
Keywords
cardiac injury, cardiac toxicity
Brief summary
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury. This study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning
Detailed description
This is a single-center retrospective study on health data. The methodology includes a collection of data on health and history data of patients treated by HBOT fo CO poisoning between 01/01/2015 and 31/12/2021 and carrying out a telephone interview of patients who have had early cardiovascular manifestations of CO poisoning. One month between the start of theses interviews, an information letter on the study is sent by post, giving the possibility of opposing it.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
Patients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015/01/01 to 2021/12/31
Exclusion criteria
* refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| early and late cardiac injury due to CO poisoning description | enrollment (inclusion) | clinical manifestation, troponin elevation and/or ECG abnormality during acute CO poisoning description; then late cardiac manifestation and abnormality declared by patients who have had early cardiac abnormality (troponin elevation and/or ECG abnormalities) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| relationship between the source of CO poisoning and cardiac injury | enrollment (inclusion) | comparison between the group of patients with early cardiac abnormalities (troponin elevation and/or ECG abnormalities) and the group of patients without early cardiac abnormalities using Ficher test |
| relationship between context of poisoning (domestic, professionnal or intentional poisoning) and cardiac injury | enrollment (inclusion) | comparison between the group of patients with early cardiac abnormalities (troponin elevation and/or ECG abnormalities) and the group of patients without early cardiac abnormalities using Ficher test |
| relationship between other possibly associated poisoning and cardiac injury | enrollment (inclusion) | comparison between the group of patients with early cardiac abnormalities (troponin elevation and/or ECG abnormalities) and the group of patients without early cardiac abnormalities using Ficher test |
| relationship between severity of neurological symptoms and cardiac injury | enrollment (inclusion) | comparison between the group of patients with early cardiac abnormalities (troponin elevation and/or ECG abnormalities) and the group of patients without early cardiac abnormalities using Ficher test |
| relationship between cardiovascular risk factors or preexisting cardio vascular abnormality and cardiac injury | enrollment (inclusion) | comparison between the group of patients with early cardiac abnormalities (troponin elevation and/or ECG abnormalities) and the group of patients without early cardiac abnormalities using Ficher test |
Countries
France
Contacts
Primary Contactanne Henckes
Outcome results
None listed