Esophageal Carcinoma
Conditions
Brief summary
This study is being done to learn how 18F-FSPG PET/CT scan results may be related to the response to chemotherapy and radiation in patients with esophageal cancer.
Detailed description
PRIMARY OBJECTIVES: I. Evaluate the ability of 18F-FSPG PET imaging to detect tumors in patients with esophageal cancer.
Interventions
OTHERNon-Interventional Study
Non-interventional study
Sponsors
M.D. Anderson Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \* ≥ 18 years of age * Patients with locally advanced esophageal cancer * Patients with untreated documented carcinoma of the esophagus that is \> 2 cm who are going to receive systemic therapy concurrently with radiation as primary therapy * Ability to provide written informed consent in accordance with institutional policies * Female subjects of childbearing potential must have a negative serum or urine pregnancy test within 1 week of the proposed investigational PET/CT scan(s) prior to injection of the investigational radiopharmaceutical
Exclusion criteria
* \* Body weight ≥ 400 pounds or body habitus or disability that will not permit the imaging protocol to be performed * Pregnant or lactating females * Have an allergy to intravenous contrast * eGFR \< 30
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Safety and adverse events (AEs) | Through study completion; an average of 1 year. | Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0 |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORSteven H Lin, MD, PHD
M.D. Anderson Cancer Center
Outcome results
None listed