Intracerebral Hemorrhage, Stroke
Conditions
Keywords
Primary intracerebral hemorrhage, Stroke, Outcomes
Brief summary
The investigators design an observational multi-center cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalized adult patients with primary intracerebral hemorrhage.
Detailed description
This cohort was an analysis based on patients from six stroke centers: the 2nd Affiliated Hospital of Zhejiang University; the First People's Hospital of Pinghu, Jiaxing; the First People's Hospital of Taizhou; the People's Hospital of Haiyan, Jiaxing; Tiantai County People's Hospital, Taizhou; the 2nd People's Hospital of Quzhou (Please see more information of this cohort in supplement). All hospitals are located in Zhejiang Province. Patients' data were entered by local trained registrars using standardised protocols, and the overall process of case registration, monitoring of the data quality, and inquiry and correction of erroneous data was managed and supervised by a steering committee. We included adult patients who (1) admitted for primary ICH ; (2) underwent blood routine test (hemoglobin included) and CT scan as soon as they arrived at hospital; (3) were not treated with neurosurgical procedures. We excluded patients who (1) had ICH secondary to known causes, including trauma, intracranial neoplasm and systemic diseases12, as well as anticoagulative agents; or had isolated intraventricular hemorrhage (IVH); (2) mRS \>2 before the current ICH episode (according to past medical records or description from guardians. This study was approved by human research ethic committees at all participating centers, and conducted in compliance with the principles set forward by the Declaration of Helsinki.
Interventions
None listed
Sponsors
The People's Hospital of Haiyan
Taizhou First People's Hospital
The First People's Hospital of Pinghu
The 2nd People's Hospital of Quzhou
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
\- We included adult patients who (1) admitted for primary ICH ; (2) underwent blood routine test (hemoglobin included) and CT scan as soon as they arrived at hospital; (3) were not treated with neurosurgical procedures.
Exclusion criteria
* We excluded patients who (1) had ICH secondary to known causes, including trauma, intracranial neoplasm and systemic diseases12, as well as anticoagulative agents; or had isolated intraventricular hemorrhage (IVH); (2) mRS \>2 before the current ICH episode (according to past medical records or description from guardians.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause death | 5 years after ICH | Patients die of any reasons |
| ICH recurrence | 5 years after ICH | Patients had an another ICH after this ictus |
| 3-month outcome | 3 months after ICH | 3-month outcome is measured using modified Rankin Scale (mRS) score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hematoma volume | up to 5 hours (A few hours after ICH) | The volume of hematoma according to CT scan at the baseline when patients arrived at the emergency room |
| hematoma expansion | within 48 hours after ICH | Patients had another CT scan during 24-48 hours after the first CT, and hematoma volume growth exceeding 33% or absolute hematoma growth exceeding 6ml |
| cerebral small vessel diseases (CSVDs) | within 2 weeks after ICH | cerebral small vessel diseases evaluated by MRI, including cortical superficial siderosis (cSS), white matter hyperintensity (WMH), cerebral microbleed (CMB), etc. |
Countries
China
Contacts
Primary ContactFeng Gao, Dr
Outcome results
None listed