Major Depressive Disorder
Conditions
Brief summary
The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).
Interventions
DEVICETMS
transcranial magnetic brain stimulation
Sponsors
VA Office of Research and Development
National Institute of Mental Health (NIMH)
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men and women, ages 18 years and up * English speaking * Military Veterans
Exclusion criteria
* Those with a contraindication for MRIs (e.g. implanted metal) * History of head trauma with loss of consciousness * History of seizures or on medications that substantially reduce seizure threshold * Neurological or uncontrolled medical disease * Active substance abuse * Currently pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change | 45 minutes | Change in the TMS-EEG measure will be assessed before, during, and after each TMS session. Specifically, the difference in size of the evoked response after a single TMS pulse in the frontoparietal region will be quantified in microVolts and compared between standard TMS and sensory-entrained TMS (se-TMS). |
Countries
United States
Contacts
CONTACTJessica M Ross, PhD
PRINCIPAL_INVESTIGATORJessica M Ross, PhD
VA Palo Alto Health Care System, Palo Alto, CA
Outcome results
None listed