Neutropenia Autoimmune
Conditions
Brief summary
There are currently no clinical and laboratory data that well characterize this neutropenia associated with the Duffy-null phenotype, particularly for pediatric subjects. In particular there are no data on the frequency of immune neutropenia in DANC neutropenic pediatric subjects. The goal of this study is to : * define the frequency of immune neutropenia within the cohort of DANC subjects under study * evaluate the frequency of different degrees of neutropenia (mild-moderate-severe); * evaluate the possible association between different degrees of neutropenia and the presence of infections.
Interventions
Retrospective collection of clinical and laboratory data relating to the definition of the nature of neutropenia
Sponsors
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Inclusion criteria
* presence of Duffy-null phenotype
Exclusion criteria
* absence of Duffy-null phenotype
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Immune neutropenia and DANC | Through study completion, an average of 1 year | Frequency of immune neutropenia, expressed as the percentage of DANC subjects testing positive for anti-neutrophil antibodies out of the total DANC subjects included in the study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distribution of mild, moderate and severe neutropenia in DANC children | Through study completion, an average of 1 year | Frequencies in percentage of mild (1000-1500 neutrophils/ul), moderate (500-1000 neutrophils/ul) and severe (\<500 neutrophils/ul) neutropenia within the DANC cohort under study |
Countries
Italy
Outcome results
None listed