Bariatric Surgery, Carbon Dioxide, Intracranial Pressure, Ventilation
Conditions
Brief summary
The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are： * Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients? * Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients? * Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP. Participants will: * take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation * monitor Respiratory mechanics, PaCO2, and ONSD
Interventions
DEVICEPC Ventilation mode
Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group I received pressure control ventilation (PC).
DEVICEVC Ventilation mode
Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group II received volume control ventilation (VC).
DEVICEPRVC Ventilation mode
Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group III received pressure-regulated volume control ventilation (PRVC).
Sponsors
Yu-Long Jia
Inner Mongolia Baogang Hospital
The Affiliated Hospital of Inner Mongolia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
16 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients scheduled for elective bariatric surgery. * Age between 16 and 65 years. * Continuous weight gain for more than 5 years with a BMI ≥ 35. * ASA-PS (American Society of Anesthesiologists Physical Status) categorization of Grade II or III.
Exclusion criteria
* Patients who were dependent on alcohol or opioids. * Patients with severe mental or intellectual disabilities. * Patients with severe ocular conditions, such as ocular trauma, optic nerve tumors, or those wearing ocular prostheses.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| optic nerve sheath diameter [ONSD] | 1 year | Patients were positioned supine with their eyes softly closed, and their eyes were protected with disposable transparent patches. A 7.5 MHz linear probe (Micromaxx Ultrasound System; SonoSite Inc., Bothell, WA, USA) was gently placed on the closed upper eyelid without applying pressure to the eyeball, and sufficient ultrasound gel was applied to ensure clear imaging. The optic nerve sheath was checked and measured 3 mm beyond the globe, and three ONSD measures were performed, with the average value utilized as the final ONSD measurement, which was accurate to 0.01 mm. |
| carbon dioxide partial pressure | 1 year | Arterial blood carbon dioxide partial pressure, is an important indicator of alveolar ventilation, reflecting the respiratory factors in acid-base balance. Its reference value is usually 35-45 mmHg. |
| mean airway pressure (PAWM) | 1 year | Mean airway pressure throughout the ventilation cycle |
| peak airway pressure (PAP) | 1 year | Maximum pressure in the airway throughout inspiration |
| esophageal pressure (PES) | 1 year | Esophageal manometry is the recording of pressure changes in various parts of the esophagus at rest and after swallowing, and is used to indicate the motor function of the upper and lower esophageal sphincters and the body of the esophagus, and to understand esophageal motility |
| tidal volume (TV) | 1 year | Tidal volume is the volume of gas inhaled or exhaled each time when breathing calmly, it is an indicator to show lung volume, mainly used for ventilation function test in pulmonary function test. Tidal volume is the basis for assessing lung function and ventilation efficiency, and is an important indicator of lung volume |
| mean arterial pressure (MAP) | 1 year | Mean arterial pressure is the average push given by the heart to blood flow throughout the cardiac cycle, with systolic pressure being the peak pressure and diastolic pressure being the pressure nadir. |
| heart rate (HR) | 1 year | The normal adult heart rate ranges from 60 to 100 beats per minute, but infants and children have a faster heart rate than adults. |
Countries
China
Contacts
Primary ContactYu-Long Jia
Outcome results
None listed