Polycystic Ovary Syndrome, Pregnancy Complications
Conditions
Keywords
Polycystic Ovary Syndrome, Pregnancy Complications, Kisspeptin, gestational diabetes mellitus, insulin resistance
Brief summary
The current study aims to investigate the dynamic serum kisspeptin levels throughout pregnancy and to explore its predictive value for GDM in PCOS.
Detailed description
The current prospective cohort study aims to investigate the dynamic serum kisspeptin levels in the patients with polycystic ovary syndrome (PCOS) at different trimesters of pregnancy, to analyze the associations between serum kisspeptin, insulin, glucose and testosterone, and to explore the predictive value of kisspeptin for GDM and other complications in PCOS patients.
Interventions
OTHERObservation
It's a observational cohort study and no interventions are performed.
Sponsors
Fudan University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18 and 40 years old * Women diagnosed as PCOS who register for prenatal check ups in the obstetrics outpatient department of hospitals during early pregnancy.(The diagnostic criteria for PCOS are based on the 2003 Rotterdam diagnostic criteria (any two out of the three key characteristics of PCOS: oligo-amenorrhea, hyperandrogenism, and polycystic-appearing ovarian morphology on ultrasonography) .
Exclusion criteria
* All other diseases with ovulation disorders or hyperandrogenism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dynamic changes of serum kisspeptin levels throughout pregnancy in PCOS patients | 40 weeks | Serum kisspeptin levels in the first, second trimester and late pregnancy of PCOS patients and control group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The association between serum Kisspeptin levels and the prevalence of GDM in PCOS patients | 40 weeks | The predictive value of serum Kisspeptin levels in the first trimester for GDM in PCOS patients |
| The association between serum Kisspeptin levels and the prevalence of insulin resistance in PCOS patients | 40 weeks | The predictive value of serum Kisspeptin levels in the first trimester for insulin resistance in PCOS patients |
Countries
China
Contacts
Primary ContactWei Zhang, phD
Outcome results
None listed