Apical Periodontitis
Conditions
Brief summary
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled for Endodontic Microsurgery at the University of Pennsylvania School of Dental Medicine, Department of Endodontics. Patients undergoing routine endodontic microsurgery and who meet the inclusion criteria will be given the opportunity to opt in to receive L-PRF in the osteotomy site to promote bone formation. Healing will be assessed radiographically and clinically at six, twelve, eighteen, and twenty-four months.
Interventions
PROCEDURELeukocyte and Platelet Rich Fibrin
Leukocyte Platelet Rich Fibrin (L-PRF) is a collection of growth factors rich in proinflammatory cells that promote healing after dental surgery. A L-PRF clot is obtained by collecting blood from the subject, similar to a phlebotomist drawing blood via venipuncture. The blood samples are spun in a centrifuge using the recommended settings by the manufacture(1). The resultant product has separated the red blood cells from the L-PRF clot which is placed back into the subject to promote healing of the surgical site.
Sponsors
University of Pennsylvania
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits. 3. Male or Female age \>18 years old. 4. In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery. 5. Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5) 6. Intact coronal restorations with no evidence of leakage or caries under the restoration.
Exclusion criteria
1. Minors. 2. Suspected root fractures. 3. ASA classification 3 or greater. 4. Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5). 5. Patients with history of Oral or IV Bisphosphonate use. 6. Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peri-radicular Healing | 12 and 24 months | Evaluate Peri-radicular healing after Endodontic Microsurgery with the use of autologous L-PRF plug. |
Countries
United States
Outcome results
None listed