Acute Kidney Injury After Cardiac Arrest

Causes and Clinical Outcomes of Acute Kidney Injury After Cardiac Arrest: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06544538

Enrollment

Registered

2024-08-09

Start date

2013-01-01

Completion date

2022-12-31

Last updated

2024-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

cardiac arrest, Acute kidney injury, Mortality

Brief summary

The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest. For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

Detailed description

This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis. Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

Exclusion criteria

* Deaths in the first 48 hours * Missing data * End stage CKD or first day hemadsorption * CPR time \<3 min * Unwitnessed cardiac arrest * Terminal malignancy * 90 years old * Having a pace marker * Massive bleeding * ECMO application * First day diyabetes insipitus

Design outcomes

Primary

Measure	Time frame	Description
Acute Kidney Injury (AKI)	Within 48 hours after intensive care unit admission	Creatinine values in the first 48 hours of intensive care unit admission after cardiac arrest

Secondary

Measure	Time frame	Description
AKI incidence	Within 48 hours after intensive care unit admission	Determination of the incidence of AKI development after cardiac arrest
Mortality	Clinical and laboratory data within 48 hours after intensive care unit admission will be used	Impact of AKI development on mortality in the early post-cardiac arrest period

Countries

Turkey (Türkiye)

Outcome results