Coronary Total Occlusion
Conditions
Keywords
CTO
Brief summary
The research aimed to evaluate the impact of a successful Percutaneous coronary intervention of chronic total occlusions (CTO-PCI) on long-term MACE (Major Cardiovascular Events), symptoms, survival, Left Ventricular Ejection Fraction (LVEF) and myocardial ischemia up-to-8-years follow-up.
Detailed description
With this observational and prospective study, this research aimed to evaluate the impact of a successful CTO-PCI on long-term MACE (Major Cardiovascular Events), symptoms, survival, LVEF and myocardial ischemia up-to-8-years follow-up.
Interventions
OTHERPercutaneous Coronary Intervention of CTO
CTO-PCI is a procedure of interventional cardiology attempting revascularisation of the CTO
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years or older * who underwent at least one CTO procedure between 2025 and 2022 in Montpellier University Hospital * symptomatic of reversible myocardial ischemia * proof of myocardial viability
Exclusion criteria
* refusal of the patient to participate to the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major cardiovascular events (MACE) | Up to 8 years | Incidence of composite of cardiac death, non-fatal myocardial infarction and new target vessel revascularization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| In-hospital events | Up to one week | Incidence of Procedural complications including death, periprocedural MI, coronary perforation, pericardial tamponade requiring drainage, local vascular complications, major bleeding, contrast induced nephropathy, stroke |
| Restenosis | Up to 8 years | Incidence of Restenosis Defined as a greater than 50% diameter stenosis at follow-up angiogram of the first dilated total occlusion. Reocclusion was defined as recurrent total occlusion of the first dilated total occlusion. |
| Non combined MACE components | Up to 8 years | Incidence of Cardiac death, non-fatal myocardial infarction and new target vessel revascularization |
| Stent thrombosis | Within 30 days after the procedure | Incidence of stent thrombosis defined as any myocardial infarction with angiographic confirmation of in-stent thrombus or unexplained death |
| LVEF | Up to 8 years | Percentage of Increase or decrease in LVEF after the CTO procedure compared with baseline LVEF |
| Ischemic burden | Up to 8 years | Comparison between pre and post-CTO ischemic tests |
Countries
France
Outcome results
None listed