Liver Metastases
Conditions
Brief summary
Liver metastases (LM) are common in various types of malignant diseases, either at the diagnosis of the primary tumour or at a later time point. While the resection of colorectal LM (CRLM) is a well-established procedure, with survival rates superior to chemotherapy alone, controversial data still exist on liver resection for non-colorectal LM (NCRLM) (2, 3). These patients comprise a diverse and heterogeneous group usually excluded from surgery due to advanced tumour stage or the presence of concomitant extrahepatic disease. To date, no randomized clinical trial on the surgical treatment of NCRLM has been conducted, and only few retrospective reports are available.The scope of this research project is to develop a large registry of patients undergoing liver surgery for non-colorectal liver metastases.
Interventions
PROCEDUREliver resection
Resection of non-colorectal liver metastases
Sponsors
Azienda Ospedaliero Universitaria Maggiore della Carita
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Signature informed consent * Age ≥ 18 years * Histologically confirmed diagnosis of NCRLM (first diagnosis or relapse) * Liver resection performed.
Exclusion criteria
* ASA IV * Severe psychiatric pathology * Unable to follow a clinical examination pattern during observation. * Patient submitted exclusively to interventional locoregional procedures other than liver resection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival | From date of enrollment until the date of death from any cause assessed up to 36 months | Overall Survival defined as the time elapsed between the date of resective surgery and the date of death for any reason. Patients who are surviving at the end of observation will be considered censored at the date of the last available follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease-free Survival | From date of enrollement until the date of first documented progression assessed up to 36 months | Disease-free Survival defined as the time from resective surgery to the date of first relapse or last available follow-up, whichever occurs first |
Contacts
Primary ContactMatteo Donadon, MD, PhD
Outcome results
None listed