Weaning From Mechanical Ventilation in Patients With Acute Brain Injury

Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06542107

Enrollment

605

Registered

2024-08-07

Start date

2024-08-06

Completion date

2026-01-16

Last updated

2026-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Brain Injury, Ventilator Lung

Keywords

mechanical ventilation, acute brain injury, weaning

Brief summary

Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator. Numerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus. We aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* acute brain injury * age \>=18 years * invasive mechanical ventilation for at least 24 hours

Exclusion criteria

* tracheostomized before ICU admission * pregnant or lactation * with cervical spinal cord injury * decision to receive palliative care within 24 hours of ICU admission

Design outcomes

Primary

Measure	Time frame	Description
weaning success	up to 7-day period (ICU stay)	successfully weaned from invasive ventilation according to WIND classification

Secondary

Measure	Time frame	Description
extubation	up to 7-day period (ICU stay)	Extubation without the need for reintubation or death within a 7-day period, or upon ICU discharge, whichever occurs first

Countries

China

Outcome results