Arterial Aneurysm Wall Enhancement on HRMRI
Conditions
Brief summary
This project proposes to establish a prospective cohort of MIA based on a preexisting multicenter MIA database and to combine multidimensional methods such as high-resolution magnetic resonance, hemodynamics, ambulatory blood pressure, and imaging histology to study aneurysm instability.
Interventions
None listed
Sponsors
Zhujiang Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-80 years old, male or infertile female; * Diagnosed as IA (intracranial aneurysm) through CTA, MRA, or DSA; And it is suitable for endovascular intervention treatment * The patient and/or their legal representative or guardian fully understand the research purpose, voluntarily participate and sign informed consent Books; * Patients willing to cooperate with high-resolution magnetic resonance imaging. * Patients willing to follow up and evaluate according to clinical research protocol requirements
Exclusion criteria
* AVM (arteriovenous malformation), Moyamoya disease, or DAVF (dural arteriovenous fistula) related aneurysms; * Patients with contraindications for high-resolution magnetic resonance imaging; * Participants in clinical trials of other drugs or medical devices; * Patients with severe underlying diseases and extremely poor clinical conditions who cannot tolerate general anesthesia surgery; * Patients with poor compliance and inability to cooperate with follow-up; * Possible or clear history of severe allergy to contrast agents; * Patients with a life expectancy of less than 2 years; * Women who are breastfeeding and preparing for pregnancy during the study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| High resolution MRI aneurysm features | 1 year | Enhancement grade was defined as follows: grade 0 for none enhancement, grade 1 for focal enhancement, involved the neck, the intermediate portion, the dome, or a bleb;grade 2 for thin annular enhancement (maximum thickness≤1 mm) , grade 3 for thick annular enhancement(maximum thickness\>1 mm) . |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative mRS score | 1 year | MRS score definition: The MRS score, also known as the Modified Rankin Scale, is a scale used to evaluate the neurological recovery status of stroke patients. It is divided into seven levels, Level 0: completely asymptomatic. Level 1: Despite symptoms, without obvious disabilities, able to complete all frequently engaged work and activities. Level 2: Mild disability, unable to complete all work and activities, but able to handle personal affairs without the need for assistance from others. Level 3: Moderate disability, requiring assistance from others to walking without assistance. Level 4: Severe disability, unable to walk without the help of others, unable to take care of one's own needs. Level 5: Severe disability, bedridden, urinary and fecal incontinence, requiring continuous care, and requiring multiple 24-hour care from others. Level 6: Death. The higher the mRS score, the worse the patient's prognosis. |
| postoperative aneurysm occlusion rate | 1 year | Raymond classification, grade I: complete embolism; Grade II: residual aneurysm neck; |
Countries
China
Outcome results
None listed