Anticariogenic Properties of Zamzam Water

Effect of Zamzam Water on Streptococcus Mutans and Oral pH in High Caries-Risk Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06538532

Enrollment

Registered

2024-08-05

Start date

2023-06-01

Completion date

2024-06-01

Last updated

2024-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries,Dental, Caries Active

Brief summary

The present study aims to evaluate and compare the effect of Zamzam water as mouthwashes in high caries-risk patients regarding: i. Streptococcus mutans (S. mutans) count. ii. Oral pH. After 3 and 6 months interval.

Detailed description

The present study aims to evaluate and compare the effect of Zamzam water mouthwashes in high caries-risk patients regarding: i. Streptococcus mutans (S. mutans) count. ii. Oral pH. all patients will be into two groups; The first group will use Zamzam water mouthwash for a six months with other preventive protocols including fissure sealants and preventive restorations wherever needed, while the second group will undergo preventive protocols only. During these six months, patients will be reassessed at three and six-month intervals regarding S. mutans count, oral pH, and caries risk level.

Interventions

OTHERZamzam water

Zamzam water

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Male or female participants aged between 18-35 years. * Systemically- free individuals. * High caries-risk patients according to ADA (American Dental Association). * Not on a medication interfering with salivary secretion. * Co-operative patients approved to participate in the study.

Exclusion criteria

* Patients who are already on any mouthwash regime. * Patients who are on any medication that would alter the salivary secretion. * Allergy to any of the ingredients of the study products.

Design outcomes

Primary

Measure	Time frame	Description
caries risk level	3 months and 6 months	According to ADA
Streptomutans count	3 months and 6 months	measurements of Colony forming unit (CFU) will be performed using blood agar and mitis salivarius-bacitracin agar (MSBA).
Salivary PH level	3 months and 6 months	using pH meter

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026